Transport of amino acids and polyamines in the malaria parasite

疟疾寄生虫中氨基酸和多胺的运输

• 批准号: nhmrc : 525428
• 负责人: Prof Kiaran Kirk
• 金额: $ 27.71万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transport-amino-acids-malaria-parasite/99975
• 关键词: Transport; amino; acids; polyamines; malaria

Malaria is one of the major infectious diseases challenging the world today. There is no effective vaccine, and the malaria parasite has developed resistance to most of the antimalarial drugs that we presently have available. This work focuses on the molecular mechanisms by which the malaria parasite takes up particular classes of nutrients from the surrounding environment. It paves the way for the exploitation of these mechanisms as new and much-needed antimalarial drug targets.

疟疾是当今世界面临的主要传染病之一。没有有效的疫苗，疟疾寄生虫已经对我们目前可用的大多数抗疟药物产生了抗药性。这项工作的重点是疟疾寄生虫从周围环境中摄取特定类别营养物质的分子机制。它为利用这些机制作为新的和急需的抗疟药物靶点铺平了道路。