Ion transport in the malaria parasite, Plasmodium falciparum

疟原虫恶性疟原虫中的离子传输

• 批准号: nhmrc : 122814
• 负责人: Prof Kiaran Kirk
• 金额: $ 15.05万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ion-transport-malaria-plasmodium-falciparum/76984
• 关键词: Ion; transport; malaria; parasite; Plasmodium

Malaria is an infectious disease caused by single-cell protozoan parasites which, during the course of their complex lifecycle, invade the red blood cells of their human hosts. In recent years the emergence and spread of malaria parasites with high levels of antimalarial drug resistance has given rise to the very real possibility that within a few years, there will be large parts of the world in which malaria is an untreatable disease. There is therefore an urgent need for new antimalarial drugs. Despite the enormous clinical significance of the malaria parasite, the basic physiology of this organism is not understood. Pathways involved in ion balance, in the uptake of essential nutrients and in the release of potentially toxic waste products all play a crucial role in the survival of the parasite and are potential chemotherapeutic targets. However the properties of these pathways are, as yet, largely unknown. This work will provide fundamental (and pharmacological) information about these pathways. It will thereby open up exciting new possibilities with regard to the chemotherapy of malaria and will provide a rational basis for a strategy in which these pathways might be exploited as antimalarial drug targets.

疟疾是一种由单细胞原生动物寄生虫引起的传染病，在其复杂的生命周期过程中，寄生虫侵入其人类宿主的红细胞。近年来，具有高度抗疟药物抗药性的疟原虫的出现和传播，已经产生了一种非常真实的可能性，即在几年内，世界上的大部分地区将出现疟疾这种无法治愈的疾病。因此，迫切需要新的抗疟疾药物。尽管疟原虫具有巨大的临床意义，但这种生物的基本生理学尚不清楚。参与离子平衡、必需营养素的摄取和潜在有毒废物的释放的途径在寄生虫的存活中都起着至关重要的作用，并且是潜在的化疗靶点。然而，这些途径的性质在很大程度上是未知的。这项工作将提供有关这些途径的基本（和药理学）信息。因此，它将为疟疾的化疗开辟令人兴奋的新的可能性，并将为一项战略提供合理的基础，在该战略中，这些途径可能被用作抗疟疾药物的目标。