A novel family of amino acid transporters in Apicomplexan parasites

顶复门寄生虫中一个新的氨基酸转运蛋白家族

• 批准号: DP150102883
• 负责人: Prof Kiaran Kirk
• 金额: $ 38.92万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-03-30 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150102883
• 关键词: novel; family; amino; acid; transporters

Apicomplexan parasites are single celled organisms that are the causative agents of major diseases in livestock and humans. However, the basic biochemistry of these intracellular parasites is poorly understood, and there are limited treatments available for the diseases these parasites cause. The project hypothesis is that a novel family of proteins that are unique to apicomplexan parasites play a key role in the uptake of essential nutrients (amino acids) into these organisms. This project aims to use a combination of genetic, biochemical and physiological methods to understand the function of these proteins, the role(s) that they play in apicomplexan biology, and their importance for parasite survival.

顶复门寄生虫是单细胞生物，是家畜和人类主要疾病的病原体。然而，这些细胞内寄生虫的基本生物化学知之甚少，并且这些寄生虫引起的疾病的治疗方法有限。该项目的假设是，一个新的蛋白质家族是apicomplexan寄生虫所特有的，在这些生物体摄取必需营养素（氨基酸）方面发挥着关键作用。该项目旨在使用遗传，生物化学和生理学方法的组合来了解这些蛋白质的功能，它们在顶复门生物学中的作用及其对寄生虫生存的重要性。