Targeting RCAN1 to treat type 2 diabetes and obesity

靶向 RCAN1 治疗 2 型糖尿病和肥胖症

• 批准号: nhmrc : 1142403
• 负责人: Prof Damien Keating
• 金额: $ 55.07万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-rcan1-treat-diabetes-obesity/1319701
• 关键词: Targeting; RCAN1; treat; type; diabetes

Obesity and impaired insulin secretion are significant contributors to Type 2 diabetes. In this project we demonstrate that a protein called RCAN1 contributes to both fat mass and insulin secretion and that this contribution is exacerbated in obesity and in Type 2 diabetes. We will identify how RCAN1 controls these major metabolic pathways with outcomes including the development of new therapeutics for obesity and Type 2 diabetes.

肥胖和胰岛素分泌受损是2型糖尿病的重要因素。在这个项目中，我们证明了一种名为RCAN1的蛋白质有助于脂肪量和胰岛素分泌，并且这种贡献在肥胖和2型糖尿病中加剧。我们将确定RCAN1如何控制这些主要的代谢途径，其结果包括开发肥胖和2型糖尿病的新疗法。