Defining how serotonin regulates gut motility

定义血清素如何调节肠道蠕动

• 批准号: DP190103525
• 负责人: Prof Damien Keating
• 金额: $ 37.14万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-06-12 至 2022-06-12
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103525
• 关键词: Defining; how; serotonin; regulates; gut

This project aims to deepen knowledge of gastrointestinal physiology, and reveal the mechanisms by which the major gastrointestinal signalling molecule, serotonin, regulates gut peristalsis. Almost all of the serotonin in our body is made in the gastrointestinal tract where it controls many functions, including how our gut wall contracts during peristalsis. Proper control of gut peristalsis and the transit of material through our bowel is important for our health. This project expects to define how serotonin controls peristalsis, where in the bowel this serotonin comes from, how serotonin communicates with the nervous system in our gastrointestinal tract, and how the cells that synthesise gut serotonin respond to contraction to trigger the secretion of serotonin.

本项目旨在加深对胃肠道生理学的认识，揭示主要胃肠道信号分子血清素调节肠道蠕动的机制。我们体内几乎所有的血清素都是在胃肠道中产生的，它控制着胃肠道的许多功能，包括我们的肠壁在蠕动过程中如何收缩。适当控制肠道蠕动和物质通过肠道的运输对我们的健康很重要。该项目希望确定5 -羟色胺如何控制蠕动，肠道中5 -羟色胺来自何处，5 -羟色胺如何与胃肠道神经系统沟通，以及合成肠道5 -羟色胺的细胞如何对收缩做出反应以触发5 -羟色胺的分泌。