The therapeutic value of targeting Wnt signalling for the treatment of Osteoarthritis

骨关节炎（OA）影响了162万澳大利亚人，对医疗保健造成了重大负担。它的特点是关节软骨损伤，骨形成增加，骨刺形成。我们的研究将确定Wnt信号通路在介导OA关节退变中的重要性，并确定在OA中调节该通路激活的机制。这将为新的治疗策略的发展提供信息，这些策略可以阻止OA中的关节损伤。

Osteoarthritis (OA) affects 1.62 million Australians and imposes a significant burden on healthcare. It is characterised by damage to joint cartilage, and increased bone formation with formation of bone spurs. Our studies will determine the importance of the Wnt signalling pathway in mediating OA joint degeneration and identify mechanisms that regulate the activation of this pathway in OA. This will inform the development of novel therapeutic strategies which could halt joint damage in OA.