Catalytic reactions involving M-E bonds

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Advances in chemical synthesis allow the construction of important classes of complex molecules, including medicinal agents, advanced materials, and fine chemicals. New or improved synthetic methods can thus have immediate impact in a number of areas of research and manufacturing. Notably, transition metal complexes (i.e., catalysts) can be used to control chemical reactivity. These catalysts permit reactions previously thought to be impossible, dramatically expanding the "toolbox" of useful synthetic reactions. However, our understanding of how these metal complexes operate remains insufficient to reliably design new reaction methods. By understanding metal reactivity, we expect to be able to expand the scope of what is considered synthetically feasible, thereby facilitating access to a variety of molecules of biomedical and materials interest.