Catalytic reactions involving M-E bonds - Synthetic and mechanistic studies

涉及 M-E 键的催化反应 - 合成和机理研究

• 批准号: 298379-2010
• 负责人: Love, Jennifer
• 金额: $ 4.44万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=456858
• 关键词: Catalytic; reactions; involving; bonds; Synthetic

The synthesis of medicinal agents, advanced materials and fine chemicals requires the availability of a broad range of chemical reactions, as well structurally diverse chemical building blocks. New synthetic methods address both of these needs and can thus have immediate impact in a number of areas of research and manufacturing. Notably, transition metal complexes (i.e., catalysts) can be used to control chemical reactivity. These catalysts permit reactions previously thought to be impossible, dramatically expanding the "toolbox" of useful synthetic reactions. However, our understanding of how these metal complexes operate remains insufficient to reliably design new reaction methods. By developing a better understanding of fundamental metal reactivity, we expect to be able to expand the scope of chemical reactions. In the course of our studies, we often uncover unexpected reactivity, which fuels innovation in my group and in others. Toward this end, the proposed research involves detailed investigations of metal-catalyzed reactions, spanning both organic and inorganic chemistry.

医药制剂、先进材料和精细化学品的合成需要广泛的化学反应，以及结构多样的化学构建块。新的合成方法满足了这两种需要，因此可以在许多研究和制造领域产生直接影响。值得注意的是，过渡金属配合物（即催化剂）可用于控制化学反应性。这些催化剂使以前认为不可能发生的反应成为可能，极大地扩展了有用合成反应的“工具箱”。然而，我们对这些金属配合物如何运作的理解仍然不足以可靠地设计新的反应方法。通过更好地了解基本金属的反应性，我们期望能够扩大化学反应的范围。在我们的研究过程中，我们经常发现意想不到的反应，这激发了我的团队和其他团队的创新。为此，建议的研究包括对金属催化反应的详细调查，涵盖有机和无机化学。