Catalytic reactions involving M-E bonds - Synthetic and mechanistic studies

医药制剂、先进材料和精细化学品的合成需要广泛的化学反应，以及结构多样的化学构件。新的合成方法满足了这两种需求，因此可以在许多研究和制造领域产生立竿见影的效果。值得注意的是，过渡金属络合物(即催化剂)可用于控制化学反应。这些催化剂允许以前被认为是不可能发生的反应，极大地扩大了有用的合成反应的“工具箱”。然而，我们对这些金属络合物如何运作的了解仍然不足以可靠地设计新的反应方法。通过更好地了解基本的金属反应性，我们预计能够扩大化学反应的范围。在我们的研究过程中，我们经常发现意想不到的反应，这推动了我的团队和其他人的创新。为此，拟议的研究涉及金属催化反应的详细研究，跨越有机化学和无机化学。

The synthesis of medicinal agents, advanced materials and fine chemicals requires the availability of a broad range of chemical reactions, as well structurally diverse chemical building blocks. New synthetic methods address both of these needs and can thus have immediate impact in a number of areas of research and manufacturing. Notably, transition metal complexes (i.e., catalysts) can be used to control chemical reactivity. These catalysts permit reactions previously thought to be impossible, dramatically expanding the "toolbox" of useful synthetic reactions. However, our understanding of how these metal complexes operate remains insufficient to reliably design new reaction methods. By developing a better understanding of fundamental metal reactivity, we expect to be able to expand the scope of chemical reactions. In the course of our studies, we often uncover unexpected reactivity, which fuels innovation in my group and in others. Toward this end, the proposed research involves detailed investigations of metal-catalyzed reactions, spanning both organic and inorganic chemistry.