Catalytic reactions involving M-E bonds - Synthetic and mechanistic studies

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The synthesis of medicinal agents, advanced materials and fine chemicals requires the availability of a broad range of chemical reactions, as well structurally diverse chemical building blocks. New synthetic methods address both of these needs and can thus have immediate impact in a number of areas of research and manufacturing. Notably, transition metal complexes (i.e., catalysts) can be used to control chemical reactivity. These catalysts permit reactions previously thought to be impossible, dramatically expanding the "toolbox" of useful synthetic reactions. However, our understanding of how these metal complexes operate remains insufficient to reliably design new reaction methods. By developing a better understanding of fundamental metal reactivity, we expect to be able to expand the scope of chemical reactions. In the course of our studies, we often uncover unexpected reactivity, which fuels innovation in my group and in others. Toward this end, the proposed research involves detailed investigations of metal-catalyzed reactions, spanning both organic and inorganic chemistry.