Integrative analysis of the iron responsive transcription factor AFT1

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Single cellular Fungi like Saccharomyces cerevisiae, commonly known as baker's or brewing yeast, must respond to a myriad of environmental challenges in order to survive in the wild. These challenges included changes in food/nutrient supplies and seasonal changes in weather. Remarkably, fungi genomes (cellular DNA) are small and encode a limited number of proteins, yet fungi are able to successful deal with environmental changes. Therefore a fundamental question of biology is how organism like yeast has adapted a limited number of proteins to perform multiple roles? Using a high tech genomics and proteomics tools, which allow us to sort through thousands of yeast genes and proteins quickly; we aim to shed light on this fundamental question.