Treatments for glomerulonephritis that harness antigen specific regulatory cells

利用抗原特异性调节细胞治疗肾小球肾炎

• 批准号: nhmrc : 1145105
• 负责人: Prof Arthur Kitching
• 金额: $ 41.24万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/treatments-glomerulonephritis-harness-regulatory-cells/1320352
• 关键词: Treatments; glomerulonephritis; harness; antigen; specific

Many forms of kidney disease are caused by the immune system targeting the kidney. We now have new data that demonstrate that these forms of autoimmune glomerulonephritis are caused by an imbalance in the numbers of kidney specific inflammatory versus regulatory cells. This project seeks to test therapies that correct that imbalance by increasing the numbers of kidney specific regulatory cells.

许多形式的肾脏疾病是由针对肾脏的免疫系统引起的。我们现在有新的数据表明，这些形式的自身免疫性肾小球肾炎是由肾脏特异性炎症细胞与调节细胞数量不平衡引起的。该项目旨在测试通过增加肾脏特异性调节细胞的数量来纠正这种不平衡的疗法。