How the kidney is injured by CD8+ cells in vasculitis

血管炎中 CD8 细胞如何损伤肾脏

• 批准号: nhmrc : GNT1084869
• 负责人: Prof Arthur Kitching
• 金额: $ 89.39万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/kidney-injured-cd8-cells-vasculitis/1345584
• 关键词: How; kidney; injured; CD8+; cells

People with severe kidney disease often have inflammation in the small blood vessels within their kidneys, known as vasculitis. Human observational studies suggest that a type of immune cell, the CD8+ cell, may be critical to disease outcome, but there is no functional evidence for this. The current studies will define the role of these CD8+ cells in disease so that better treatments for humans with vasculitis can be considered.

患有严重肾脏疾病的人通常会在肾脏内的小血管中出现炎症，称为血管炎。人类观察研究表明，一种免疫细胞，CD8+细胞，可能对疾病结果至关重要，但没有功能证据表明这一点。目前的研究将确定这些CD8+细胞在疾病中的作用，以便考虑更好地治疗人类脉管炎。