Immunoregulation in the Pathogenesis and Therapy of Autoimmune anti Myeloperoxidase Glomerulonephritis
Immunoregulation in the Pathogenesis and Therapy of Autoimmune anti Myeloperoxidase Glomerulonephritis
批准号:
nhmrc : 606684
负责人:
Prof Arthur Kitching
金额:
$18.93万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31
中文摘要
肾小球肾炎(GN)是一种主要的健康负担,新月体肾炎是最严重的形式。大多数患者都有针对自身白血球ANCA的自身抗体,从而导致了这种疾病。这项研究将使用ANCA相关性自身免疫导致新月体肾炎的小鼠模型来确定阻止这种疾病发展的正常机制(免疫调节),并测试新的基于细胞的疗法来预防和治疗这种疾病的可能性。
英文摘要
Glomerulonephritis (GN) is a major health burden and crescentic GN is the most severe form. Most patients have autoantibodies to their own white blood cell ANCA, causing the disease. This study will use a mouse model of ANCA associated autoimmunity causing crescentic GN to define the normal mechanisms preventing the development of this disease (immunoregulation) and test the potential of new cell based therapies to prevent and treat the disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Treatments for glomerulonephritis that harness antigen specific regulatory cells
-
批准号:nhmrc : 1145105
-
项目类别:Project Grants
-
资助金额:$41.24万
-
财政年份:2018
-
负责人:Prof Arthur Kitching
-
依托单位:
Conventional and unconventional T cells in interstitial kidney disease
-
批准号:nhmrc : GNT1139719
-
项目类别:Project Grants
-
资助金额:$48.05万
-
财政年份:2018
-
负责人:Prof Arthur Kitching
-
依托单位:
Conventional and unconventional T cells in interstitial kidney disease
-
批准号:nhmrc : 1139719
-
项目类别:Project Grants
-
资助金额:$32.49万
-
财政年份:2018
-
负责人:Prof Arthur Kitching
-
依托单位:
Cytokine Inhibition as a Potential Therapy for ANCA-Associated Glomerulonephritis
-
批准号:nhmrc : 1128267
-
项目类别:Project Grants
-
资助金额:$63.51万
-
财政年份:2017
-
负责人:Prof Arthur Kitching
-
依托单位:
Monocytes on patrol – key mediators of renal injury in glomerulonephritis
-
批准号:nhmrc : 1124459
-
项目类别:Project Grants
-
资助金额:$52.81万
-
财政年份:2017
-
负责人:Prof Arthur Kitching
-
依托单位:
Cytokine Inhibition as a Potential Therapy for ANCA-Associated Glomerulonephritis
-
批准号:nhmrc : GNT1128267
-
项目类别:Project Grants
-
资助金额:$92.96万
-
财政年份:2017
-
负责人:Prof Arthur Kitching
-
依托单位:
Monocytes on patrol – key mediators of renal injury in glomerulonephritis
-
批准号:nhmrc : GNT1124459
-
项目类别:Project Grants
-
资助金额:$77.29万
-
财政年份:2017
-
负责人:Prof Arthur Kitching
-
依托单位:
RELapses prevENTion in chronic autoimmune disease: common mechanisms and co-morbidities (RELENT)
-
批准号:nhmrc : GNT1115805
-
项目类别:International Collaborations
-
资助金额:$49.98万
-
财政年份:2016
-
负责人:Prof Arthur Kitching
-
依托单位:
The Role of Inflammasomes in Renal Vasculitis
-
批准号:nhmrc : GNT1104422
-
项目类别:Project Grants
-
资助金额:$87.6万
-
财政年份:2016
-
负责人:Prof Arthur Kitching
-
依托单位:
The Role of Inflammasomes in Renal Vasculitis
-
批准号:nhmrc : 1104422
-
项目类别:Project Grants
-
资助金额:$60.27万
-
财政年份:2016
-
负责人:Prof Arthur Kitching
-
依托单位:
RELapses prevENTion in chronic autoimmune disease: common mechanisms and co-morbidities (RELENT)
-
批准号:nhmrc : 1115805
-
项目类别:Targeted Calls
-
资助金额:$34.36万
-
财政年份:2016
-
负责人:Prof Arthur Kitching
-
依托单位:
How the kidney is injured by CD8+ cells in vasculitis
-
批准号:nhmrc : GNT1084869
-
项目类别:Project Grants
-
资助金额:$89.39万
-
财政年份:2015
-
负责人:Prof Arthur Kitching
-
依托单位:
How the kidney is injured by CD8+ cells in vasculitis
-
批准号:nhmrc : 1084869
-
项目类别:Project Grants
-
资助金额:$61.93万
-
财政年份:2015
-
负责人:Prof Arthur Kitching
-
依托单位:
Imaging neutrophil and endothelial function in acute glomerulonephritis
-
批准号:nhmrc : 1064112
-
项目类别:Project Grants
-
资助金额:$36.38万
-
财政年份:2014
-
负责人:Prof Arthur Kitching
-
依托单位:
Intravascular Immunity in Glomerulonephritis
-
批准号:nhmrc : 1045165
-
项目类别:Project Grants
-
资助金额:$39.08万
-
财政年份:2013
-
负责人:Prof Arthur Kitching
-
依托单位:
Mechanisms of infection triggered renal vasculitis
-
批准号:nhmrc : 1008849
-
项目类别:NHMRC Project Grants
-
资助金额:$27.6万
-
财政年份:2011
-
负责人:Prof Arthur Kitching
-
依托单位:
Mechanisms of Th17 induced injury in the kidney
-
批准号:nhmrc : 1010563
-
项目类别:Project Grants
-
资助金额:$31.71万
-
财政年份:2011
-
负责人:Prof Arthur Kitching
-
依托单位:
Mechanisms of Disease in Humans with MPO-ANCA Associated Glomerulonephritis
-
批准号:nhmrc : 606683
-
项目类别:NHMRC Project Grants
-
资助金额:$35.58万
-
财政年份:2010
-
负责人:Prof Arthur Kitching
-
依托单位:
Mechanisms of Glomerular Leukocyte Recruitment
-
批准号:nhmrc : 606564
-
项目类别:NHMRC Project Grants
-
资助金额:$39.1万
-
财政年份:2010
-
负责人:Prof Arthur Kitching
-
依托单位:
The role of renal dendritic cells in infection and immunity under immunosuppression
-
批准号:nhmrc : 565033
-
项目类别:NHMRC Project Grants
-
资助金额:$31.68万
-
财政年份:2009
-
负责人:Prof Arthur Kitching
-
依托单位:
海外基金