Monocytes on patrol – key mediators of renal injury in glomerulonephritis

单核细胞巡逻 — 肾小球肾炎肾损伤的关键介质

• 批准号: nhmrc : GNT1124459
• 负责人: Prof Arthur Kitching
• 金额: $ 77.29万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/monocytes-patrol-key-injury-glomerulonephritis/1347406
• 关键词: Monocytes; patrol; key; mediators; renal

The glomerulus is the filtering component of the kidney. In many diseases, it can be the target of an inappropriate inflammatory response. As part of this response, white blood cells accumulate in the glomerulus where they cause damage. In this project, we make use of special microscopes to examine the glomerulus during an inflammatory response, with the aim of understanding the actions of white blood cells present in glomeruli and how they cause inflammation and damage the glomerulus.

肾小球是肾脏的过滤组件。在许多疾病中，它可能是不适当的炎症反应的目标。作为这种反应的一部分，白色血细胞积聚在肾小球中，在那里它们造成损害。在本项目中，我们使用特殊的显微镜来检查炎症反应期间的肾小球，目的是了解肾小球中存在的白色血细胞的活动以及它们如何引起炎症和损害肾小球。