Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
批准号:
10415881
负责人:
Johnnye L Lewis
金额:
$424.96万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-09-21 至 2023-08-31
关键词:
4 year oldAddressAffectAgeAntibodiesAreaAutoantibodiesAutoimmune ResponsesBehavioralBiological MonitoringBirthBrainCharacteristicsCheyenneChildChild DevelopmentChild HealthChild RearingCohort StudiesCommunicable DiseasesComplexCongenital AbnormalityDataData SourcesDevelopmentDiseaseEnrollmentEnvironmentEnvironmental ExposureEnvironmental ImpactExposure toExtended FamilyFathersFundingHealthHigh PrevalenceHomeImmuneInfant MortalityInflammationInfrastructureKnowledgeLeadLymphocyteMeasurementMeasuresMeconiumMediationMetabolic syndromeMetal exposureMetalsMothersNative AmericansNavajoNutrition SurveysNutritionalObesityOutcomeParticipantPatternPoliciesPopulationPostpartum PeriodPovertyPredispositionPregnancyPrevalenceProtocols documentationRecruitment ActivityResearchRiskRiversSerumSioux IndiansSpecimenSurveysTestingTimeTribesUnemploymentUnited StatesUnited States National Institutes of HealthUraniumUrineWorkadolescent suicidebaseclinical carecohortcytokinedevelopment policydiversity and inclusiondrinking waterearly childhoodearly life exposurefetalfollow-upgenetic analysisimmune functionimmunoregulationmortalityneurodevelopmentobesity in childrenoffspringpostnatalprenatalprogramsresilienceresponsescreeningsocialsocial determinantssuicide ratetoxicanttoxicant interactiontribal Nationtribal communitytribal landsvirtualwasting
中文摘要
摘要
紧急美洲原住民回声队列将建立在积极的纳瓦霍出生队列研究(NBCS)的基础上,
将后续期限延长到目前的12个月协议之外,并增加了另外两个部落,即
夏延河和奥格拉拉苏族部落,以评估环境暴露对废弃环境的影响
地雷废物对出生结果和儿童发育的影响。这项研究是第一次大规模的
与部落合作,在部落人口中进行环境暴露和儿童健康
并将帮助建立部落内部的研究能力以及部落工作人员的能力
进行详细的发展评估。这项研究将跟踪被录取的儿童的发展,直到
5岁跟踪神经和身体发育相对于环境的轨迹或模式
暴露于部落土地上或附近废弃的硬岩和铀矿产生的金属混合物。确实有
在美国西部有161,000个这样的废弃矿井,其中4,000个废弃的铀矿通常是
没有围栏,没有标记,儿童可以进入。仅在纳瓦霍民族,就有500多个被遗弃的铀
自上一座煤矿关闭以来,矿山30多年来一直没有得到修复。拟议的研究将
解决ECHO计划确定的两个关键健康结果重点领域
产前和儿童早期接触对1)神经发育和2)肥胖的影响。基于该团队的
初步发现,这项研究将集中在暴露在空气中导致的免疫功能失调
妊娠期间的金属混合物,以及这种失调导致神经发育的机制
延误和肥胖。这项工作将作为美国国立卫生研究院环境研究联盟的一部分进行
对儿童健康结果的影响(ECHO),将试图将多达50,000名儿童聚集在一起
从现有的出生队列研究中了解毒物、社会、营养和
文化环境对发展轨迹的影响。纳入美洲原住民队列将为
该联盟首次深入研究了#年土著人口正常儿童发展的进展情况
此外,环境逆境如何影响这一进程。美洲土著人的死亡率要高得多。
贫穷和失业,缺乏包括清洁饮用水和下水道在内的许多基本基础设施,以及
教育完成率较低。然而,他们也有很强的文化认同,在儿童方面的力量-
来自大家庭的养育,以及对重大发展里程碑的欣赏差异
与发展韧性有关,这有助于克服逆境。因此,他们的
将了解暴露对这些重要健康后果的影响纳入这一努力将带来
这不仅有助于我们通过纳入以下内容来了解美国的发展
以主权部落国家为代表的多样性,但也将有利于部落向
制定政策和临床护理,提高儿童发挥其最大潜能的能力。
英文摘要
Summary
The URGENT Native American ECHO Cohort will build on the active Navajo Birth Cohort Study (NBCS),
extending the follow up period beyond the current 12 month protocol, and adding two additional tribes, the
Cheyenne River and Oglala Sioux Tribes, to assess the impact of environmental exposures to abandoned
mine waste on birth outcomes and child development. The study, the first large-scale assessment of
environmental exposures and children’s health in tribal populations is conducted in partnership with tribal
communities and will help to build both research capacity within the tribes as well as capacity of tribal staff to
conduct detailed developmental assessments. The study will follow development of the enrolled children until
age 5 to track trajectories or patterns of neuro- and physical development with respect to environmental
exposures to metal mixtures from abandoned hard rock and uranium mines on or near tribal lands. There are
161,000 such abandoned mines in the Western US, 4,000 of them abandoned uranium mines which are often
unfenced, unmarked and accessible to children. On Navajo Nation alone, more than 500 abandoned uranium
mines remain un-remediated more than 30 years since the closing of the last mine. The proposed research will
address two of the key health outcome focus areas identified by the ECHO program through study of the
effects of prenatal and early childhood exposure on 1) neurodevelopment, and 2) obesity. Based on the team’s
preliminary findings, the research will focus on dysregulation of immune function as a result of exposure to
metal mixtures during gestation, and mechanisms by which this dysregulation can lead to neurodevelopmental
delays and obesity. The work will be conducted as part of the NIH Consortium to study Environmental
Influences on Child Health Outcomes (ECHO) which will attempt to bring together as many as 50,000 children
from existing birth cohort studies to understand the complex interactions of toxicant, social, nutritional, and
cultural environments on developmental trajectories. Inclusion of the Native American Cohort will bring to the
Consortium the first in-depth look at how normal child development progresses in Native populations in
addition to how environmental adversity affects that course. Native Americans have far greater rates of
poverty and unemployment, lack much essential infrastructure including clean drinking water and sewers, and
have lower educational completion rates. However, they also have strong cultural identities, strength in child-
rearing from extended families, and differences in appreciation of significant developmental milestones that
have been associated with the development of resilience that helps in overcoming adversity. Therefore, their
inclusion in this effort to understand the effects of exposure on these important health outcomes will bring a
perspective that will serve not only to inform our understanding of development in the US through inclusion of
the diversity represented by the sovereign tribal nations, but will also be of benefit to the tribes in informing the
development of policies and clinical care that enhances the ability of children to reach their maximum potential.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
-
批准号:9903340
-
项目类别:
-
资助金额:$127.13万
-
财政年份:2017
-
负责人:Johnnye L Lewis
-
依托单位:
Promoting Diversity in the UNM METALS SRC through Risk-Reduction Research on Tribal Lands
-
批准号:10395130
-
项目类别:
-
资助金额:$5.0万
-
财政年份:2017
-
负责人:Johnnye L Lewis
-
依托单位:
Administrative Core
-
批准号:10353207
-
项目类别:
-
资助金额:$14.95万
-
财政年份:2017
-
负责人:Johnnye L Lewis
-
依托单位:
Administrative Core
-
批准号:10707536
-
项目类别:
-
资助金额:$17.3万
-
财政年份:2017
-
负责人:Johnnye L Lewis
-
依托单位:
UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
-
批准号:9544216
-
项目类别:
-
资助金额:$128.77万
-
财政年份:2017
-
负责人:Johnnye L Lewis
-
依托单位:
UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
-
批准号:9930893
-
项目类别:
-
资助金额:$1.05万
-
财政年份:2017
-
负责人:Johnnye L Lewis
-
依托单位:
UNM Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest (METALS) Superfund Research Program
-
批准号:10353201
-
项目类别:
-
资助金额:$183.9万
-
财政年份:2017
-
负责人:Johnnye L Lewis
-
依托单位:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
-
批准号:10191069
-
项目类别:
-
资助金额:$424.96万
-
财政年份:2016
-
负责人:Johnnye L Lewis
-
依托单位:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
-
批准号:10205869
-
项目类别:
-
资助金额:$32.09万
-
财政年份:2016
-
负责人:Johnnye L Lewis
-
依托单位:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
-
批准号:10745236
-
项目类别:
-
资助金额:$448.94万
-
财政年份:2016
-
负责人:Johnnye L Lewis
-
依托单位:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
-
批准号:9355734
-
项目类别:
-
资助金额:$364.2万
-
财政年份:2016
-
负责人:Johnnye L Lewis
-
依托单位:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
-
批准号:9263578
-
项目类别:
-
资助金额:$107.56万
-
财政年份:2016
-
负责人:Johnnye L Lewis
-
依托单位:
A Prospective Birth Cohort Study Involving Uranium Exposure in the Navajo Nation
-
批准号:8132584
-
项目类别:
-
资助金额:$99.98万
-
财政年份:2010
-
负责人:Johnnye L Lewis
-
依托单位:
A Prospective Birth Cohort Study Involving Uranium Exposure in the Navajo Nation
-
批准号:8287963
-
项目类别:
-
资助金额:$58.31万
-
财政年份:2010
-
负责人:Johnnye L Lewis
-
依托单位:
A Prospective Birth Cohort Study Involving Uranium Exposure in the Navajo Nation
-
批准号:8893814
-
项目类别:
-
资助金额:$100.0万
-
财政年份:2010
-
负责人:Johnnye L Lewis
-
依托单位:
A Prospective Birth Cohort Study Involving Uranium Exposure in the Navajo Nation
-
批准号:8726805
-
项目类别:
-
资助金额:$100.0万
-
财政年份:2010
-
负责人:Johnnye L Lewis
-
依托单位:
A Prospective Birth Cohort Study Involving Uranium Exposure in the Navajo Nation
-
批准号:8880335
-
项目类别:
-
资助金额:$41.69万
-
财政年份:2010
-
负责人:Johnnye L Lewis
-
依托单位:
A Prospective Birth Cohort Study Involving Uranium Exposure in the Navajo Nation
-
批准号:9127757
-
项目类别:
-
资助金额:$131.0万
-
财政年份:2010
-
负责人:Johnnye L Lewis
-
依托单位:
A Prospective Birth Cohort Study Involving Uranium Exposure in the Navajo Nation
-
批准号:8706605
-
项目类别:
-
资助金额:$100.0万
-
财政年份:2010
-
负责人:Johnnye L Lewis
-
依托单位:
A Prospective Birth Cohort Study Involving Uranium Exposure in the Navajo Nation
-
批准号:8071958
-
项目类别:
-
资助金额:$99.98万
-
财政年份:2010
-
负责人:Johnnye L Lewis
-
依托单位:
海外基金