Understanding spinal cord cyst development

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Spinal cord cysts can develop after spinal injury or in association with tumours or congenital abnormalities of the spine. These cysts often cause pain and paralysis. Treatment is often ineffective, partly because the source of the cyst fluid is unknown. We are investigating the origin of this fluid using animal models of spinal cord cysts, computer simulations, and MRI studies of patients with spinal cord cysts. Understanding the origin of cyst fluid will help us to develop improved treatment.