Ussing chamber station for the measurement of current produced by transpithelial ion movement

该设备申请用于一个Ussing室站。萨斯喀彻温大学的一名新教员将使用该仪器测量盐在细胞中运动产生的电流。申请人将在其研究计划中广泛使用该设备，测量气道（或气管）细胞中氯化物（盐的一种成分）的运动。从长远来看，他的研究计划将开发一个更深入的知识，蛋白质称为通道，允许氯离子的运动出细胞和气道表面。氯化物将水带走，从而适当地水合气道并保护其免受感染。这项研究将有助于更好地了解影响加拿大人的呼吸系统疾病，如囊性纤维化、哮喘和慢性阻塞性肺疾病（COPD），并将有助于开发创新治疗方法。这种新设备对于有效执行申请人的研究计划至关重要。唯一可用的设备是25岁，缓慢，不可靠，有时不准确。新设备由于容量更大，将更快地得出结果，由于其年龄和质量而可靠，由于其新的电子设备而提供更准确的结果，并同时运行更多的样品。

This equipment request is for an Ussing chamber station. This apparatus will be used by a new faculty member at the University of Saskatchewan for the measurement of current produced by salt movement across cells. The applicant will make extensive use of the equipment in his research program by measuring the movement of chloride, a component of salt, in cells lining the airway (or windpipe). In the long term, his research program will develop a more in-depth knowledge of proteins called channels that allow the movement of chloride out of cells and onto the airway surface. The chloride pulls water with it, thus properly hydrating the airway and protecting it against infection. This research will lead to a better understanding of respiratory diseases that impact Canadians, such as cystic fibrosis, asthma, and chronic obstructive pulmonary disease (COPD), and will lead to the development of innovative treatments. This new equipment is crucial for effective execution of the research program of the applicant. The only equipment available is 25 years old, slow, unreliable, and at times inaccurate. The new equipment will produce results faster because of its larger capacity, be reliable because of its age and quality, give more accurate results because of its new electronics, and run more samples simultaneously.