Computational modeling of gene regulation

本研究计划的目的是开发计算技术来表征和模拟转录因子及其结合位点之间的识别。转录因子是细胞中非常重要的蛋白质，它与基因的启动子或其他调控区域结合并调节其转录活性。转录因子或其结合位点的突变往往导致基因在错误的时间或错误的地点转录和产生蛋白质；因此往往是癌症或其他疾病的原因。

The aim of this research proposal is to develop computational techniques to characterize and model the recognition between transcription factor and its binding sites. Transcription factors (TFs) are very important proteins in the cell that bind to the promoter or other regulatory regions of genes and modulate their transcription activity. Mutations on the transcription factors or their binding sites often result in the genes being transcribed and proteins produced at the wrong time or wrong place; thus are often the causes of cancer or other disorders.