Computational modeling of gene regulation

基因调控的计算模型

• 批准号: 327612-2009
• 负责人: Zhang, Zhaolei
• 金额: $ 1.82万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=481800
• 关键词: Computational; modeling; gene; regulation

The aim of this research proposal is to develop computational techniques to characterize and model the recognition between transcription factor and its binding sites. Transcription factors (TFs) are very important proteins in the cell that bind to the promoter or other regulatory regions of genes and modulate their transcription activity. Mutations on the transcription factors or their binding sites often result in the genes being transcribed and proteins produced at the wrong time or wrong place; thus are often the causes of cancer or other disorders.

这项研究计划的目的是开发计算技术来表征转录因子及其结合位点之间的识别并对其进行建模。转录因子是细胞中非常重要的蛋白质，它与基因的启动子或其他调节区结合，调节其转录活性。转录因子或其结合位点上的突变往往会导致基因被转录，并在错误的时间或错误的地点产生蛋白质；因此，往往是癌症或其他疾病的原因。