Cellular analysis of mammalian circadian rhythms

哺乳动物昼夜节律的细胞分析

• 批准号: 170040-2011
• 负责人: Ralph, Martin
• 金额: $ 2.26万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=476169
• 关键词: Cellular; analysis; mammalian; circadian; rhythms

The ability of animals to remember the time of day that significant conditions occur, then to anticipate the recurrence of those conditions on successive days, can have enormous adaptive significance. The daily activity of animals, including human beings, is driven in part by biological clocks that optimize the organism's physiology and behaviour with the changing conditions in the environment as well as within the organism itself. Our research is aimed at understanding how animals can remember the time, location and severity of significant happenings, then react to conditions that suggest to them that under similar conditions, similar consequences will occur. The well described hypothalamic circadian clock in the suprachiasmatic nucleus, is not necessary for the acquisition nor recall of these events. Our research examines the circadian oscillator, or oscillators, that are responsible for registering the time of day that significant events occur, then signalling to the organism, the likelihood that similar conditions are going to occur again, and at what time.

动物能够记住一天中重要条件发生的时间，然后预测这些条件在连续几天的重现，这可能具有巨大的适应意义。包括人类在内的动物的日常活动部分是由生物钟驱动的，生物钟随着环境以及生物体本身的变化而优化生物体的生理和行为。我们的研究旨在了解动物如何记住重大事件的时间、地点和严重程度，然后对暗示它们在类似条件下会发生类似后果的条件做出反应。在视交叉上核中的下丘脑昼夜节律钟，对于这些事件的获得或回忆是不必要的。我们的研究检查了昼夜节律振荡器，或振荡器，负责记录一天中发生重大事件的时间，然后向生物体发出信号，类似情况再次发生的可能性，以及何时发生。