Novel methods in computational anatomy: Quantifying structure and function via multidimensional analysis of cross sectional and longitudinal MR scans

计算解剖学的新方法：通过横截面和纵向 MR 扫描的多维分析来量化结构和功能

• 批准号: 298253-2009
• 负责人: Beg, MirzaFaisal
• 金额: $ 1.82万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=480643
• 关键词: Novel; methods; computational; anatomy; Quantifying

The escalating social and personal burdens of mental illnesses and CVDs on health and productivity are staggering. CVD remains the largest killer in the western world, mental illness accounts for 15% of the entire disease burden- an impact greater than the sum of all cancers. While 2% of Canadians between 60-74 years of age suffer from Alzheimer's and related dementias, one in three Canadians over the age of 85 are afflicted. By 2011, the number of new dementia cases per year will rise to 111,000 and by 2025 over one million Canadians are expected to suffer from Alzheimer's disease and related dementias. Parkinson's disease, the second most common neurodegenerative disorder, affects approximately 100,000 Canadians, costs the Canadian health care system approximately $2.5B annually, in addition to the tremendous toll on patients and their families. As the baby boomers age, the disproportionate number of dementia cases and CVDs will create a 'tsunami' that will threaten our medical system in the years to come.

精神疾病和心血管疾病对健康和生产力造成的社会和个人负担不断升级，令人震惊。 CVD 仍然是西方世界最大的杀手，精神疾病占整个疾病负担的 15%，其影响大于所有癌症的总和。 60-74 岁之间的加拿大人中有 2% 患有阿尔茨海默氏症和相关痴呆症，而 85 岁以上的加拿大人中有三分之一患有此病。到 2011 年，每年新发痴呆症病例数将增至 111,000 例，到 2025 年，预计将有超过 100 万加拿大人患有阿尔茨海默病和相关痴呆症。帕金森病是第二常见的神经退行性疾病，影响着大约 100,000 名加拿大人，每年给加拿大医疗保健系统造成约 $2.5B 的损失，此外还给患者及其家人造成巨大损失。随着婴儿潮一代的老龄化，痴呆症病例和心血管疾病的数量过多将引发一场“海啸”，在未来几年威胁我们的医疗系统。