High resolution dosimetric detector for synchrotron microbeam cancer therapy

用于同步加速器微束癌症治疗的高分辨率剂量检测器

• 批准号: 381069-2009
• 负责人: Kasap, Safa
• 金额: $ 8.51万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=484885
• 关键词: resolution; dosimetric; detector; synchrotron; microbeam

The recent availability of the Biomedical Imaging and Therapy (BMIT) beam line at the Canadian Light Source (CLS) in Saskatoon is a truly exceptional and a unique opportunity to carry out research that has impact in the overall target area of biomedical technologies. During this strategic grant we propose to develop a high resolution dosimetric detector for use in monitoring the high dose profile in Microbeam Radiation Therapy (MRT). Microbeam Radiation Therapy is based on the irradiation of tumors with microplanar arrays of intense synchrotron-generated x-rays. Irradiation with parallel arrays of thin, planar slices of x-ray beams spares the normal tissue, including the central nervous system, and preferentially damages tumors. MRT has been shown to be of great benefit in cancer therapy, and relies on the availability of a synchrotron source - hence the exceptional and unique opportunity in Canada. One of the biggest problems in applying MRT is the measurement of the high dose profile in the synchrotron generated beam, since the dose is large and varies over distances of micrometers. Thus, a high spatial resolution, high dynamic range dosimetric detector is needed to be able to perform MRT. We propose a novel high resolution dosimetric detector plate which is based on the conversion of rare-earth (RE) ions in a glass or glass-ceramic plate to another oxidation state by the incident high dose radiation. The converted amount depends on the dose and is highly localized to the incident radiation region. The fluorescence emission from the new oxidation state (after suitable excitation) of the RE ion can be easily distinguished from that from unconverted ions. Fluoroscopic confocal imaging, with filters to remove the emission from unconverted RE ions, will be used to obtain the dose distribution. Further, the research will aim to develop reusable dosimetric plates, and will optimize the RE-doped plate medium, response and the read-out optics for high resolution measurements. The strategic project has direct enormous health benefits to Canada, uses the Canadian synchrotron, and trains HQP in interdisciplinary experimental skills.

最近在萨斯卡通加拿大光源（CLS）的生物医学成像和治疗（BMIT）光束线的可用性是一个真正的例外和独特的机会，可以开展对生物医学技术总体目标领域产生影响的研究。在这一战略拨款期间，我们建议开发一种高分辨率剂量计探测器，用于监测微束放射治疗（MRT）的高剂量谱。微束放射治疗是以同步加速器产生的强x射线微平面阵列照射肿瘤为基础的。用平行排列的x射线薄平面片照射，可以保护包括中枢神经系统在内的正常组织，并优先损害肿瘤。MRT已被证明在癌症治疗中有很大的好处，并且依赖于同步加速器源的可用性-因此在加拿大有特殊和独特的机会。应用MRT的最大问题之一是测量同步加速器产生的光束中的高剂量分布，因为剂量很大并且在微米距离上变化。因此，需要一个高空间分辨率、高动态范围的剂量计探测器来执行MRT。我们提出了一种新型的高分辨率剂量测量检测板，它是基于入射高剂量辐射将玻璃或玻璃陶瓷板中的稀土离子转化为另一氧化态。转换量取决于剂量，并高度局限于入射辐射区域。稀土离子的新氧化态（在适当激发后）的荧光发射可以很容易地与未转化离子的荧光发射区分。荧光共聚焦成像，滤光片去除未转换的RE离子的辐射，将用于获得剂量分布。此外，该研究将致力于开发可重复使用的剂量测定板，并将优化re掺杂板介质，响应和读出光学器件，以实现高分辨率测量。该战略项目对加拿大有直接的巨大的健康效益，使用加拿大同步加速器，并在跨学科实验技能方面培训HQP。