Molecular analysis of chromatin assembly

“表观遗传学”的一个定义是一种不严格由DNA序列决定的稳定的遗传遗传形式。表观遗传调控可以支持基因组基因座对特定转录状态的承诺。转录的表观遗传调控的破坏可能导致疾病的发展。近年来，表观遗传调控大多发生在染色质结构水平，这一点已变得十分明显。染色质结构的一种调节方式发生在染色质组装的水平上，染色质组装是真核生物中进化上保守的过程，DNA被包装在组蛋白中。

One definition of "epigenetics" is a stable form of genetic inheritance that is not strictly determined by DNA sequence. Epigenetic regulation can underlie the commitment of a genomic locus to a specific transcriptional state. The disruption of epigenetic regulation of transcription can lead to disease development. In recent years it has become clear that most epigenetic regulation occurs at the level of chromatin structure. One way chromatin structure is regulated occurs at the level of chromatin assembly, the evolutionarily conserved process in eukaryotes where DNA is packaged within histones.