Breed-specific gene expression profiles and DNA methylation patterns in calves infected with Mycobacterium avium subsp. paratuberculosis (MAP)

感染鸟分枝杆菌亚种的小牛的品种特异性基因表达谱和 DNA 甲基化模式。

• 批准号: 391241-2009
• 负责人: Karrow, Niel
• 金额: $ 5.21万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=486105
• 关键词: Breed; specific; gene; expression; profiles

Johne's disease (JD) is a widespread and economically important chronic inflammatory disease ofthe small intestine of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP). The prevalence of JD in Canada is estimated to be between 10 and 40% in dairy herds, which accounts for nearly 15 million dollars to the dairy industry, alone. Differences in the susceptibility to MAP infection appear to exist amongst dairy breeds, with Jerseys being more susceptible than the Holstein breed. In humans, a potential link between MAP exposure and Crohn's disease suggests that this pathogen also appears an impOltant food safety concern. Therefore, it is important that the dairy industry develops strategies for reducing the incidence of MAP infections in dairy cattle, and genetic selection might be one such approach. In order to do this, we are

约翰氏病（JD）是由鸟分枝杆菌（Mycobacterium avium subsp.）副结核病（MAP）。据估计，JD在加拿大奶牛群中的患病率在10%至40%之间，仅乳制品行业就占近1500万美元。MAP感染的易感性的差异似乎存在于奶牛品种之间，与球衣比荷斯坦奶牛品种更容易受到影响。在人类中，MAP暴露和克罗恩病之间的潜在联系表明，这种病原体也似乎是一个重要的食品安全问题。因此，重要的是，乳制品行业的发展战略，减少发病率的MAP感染奶牛，遗传选择可能是这样的方法之一。为此，我们