High-performance liquid chromatography for small molecule purification

用于小分子纯化的高效液相色谱

• 批准号: 421986-2012
• 负责人: Nodwell, Justin
• 金额: $ 8.65万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=495698
• 关键词: performance; liquid; chromatography; small; molecule

I request funds for a High Throughput Liquid Chromatography apparatus or HPLC to purify and characterize small molecules from natural sources. This apparatus will be applied to research in my laboratory that deals with the discovery and understanding of "natural products", molecules like penicillin that are produced by environmental microorganisms and which have been successfully developed for many vital purposes. These include the antibiotics used in human and veterinary medicine, anti-cancer drugs, pesticides, herbicides and many other molecules.

我申请资金用于高通量液相色谱仪或HPLC，以纯化和表征天然来源的小分子。这个装置将被应用于我实验室的研究，涉及“天然产物”的发现和理解，这些天然产物是由环境微生物产生的分子，如青霉素，已经成功地开发用于许多重要目的。其中包括用于人类和兽医学的抗生素、抗癌药物、杀虫剂、除草剂和许多其他分子。