System analysis of thermosensation in E. coli

大肠杆菌热感系统分析

• 批准号: 371880-2009
• 负责人: Ryu, William
• 金额: $ 2.19万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=498061
• 关键词: System; analysis; thermosensation; E.; coli

From a broad perspective, exposure to environmental temperature changes is a universal condition of living organisms. How biochemical and neuronal networks process temperature information or remain robust to temperature variation is not well understood. The aim of this research is to develop a deeper understanding of the network of proteins that allows bacteria to perform chemotaxis and thermotaxis, that is to sense and swim towards food or a preferred temperature, respectively. We propose to develop such an understanding through closely coupled experimental approaches and computational modeling. As all signaling pathways within living cells must function in the context of fluctuating thermal environments, our efforts may reveal universal mechanisms by which cells ensure faithful signaling.

从广义上讲，暴露于环境温度变化是生物体的普遍条件。生物化学和神经网络如何处理温度信息或对温度变化保持鲁棒性还不清楚。这项研究的目的是更深入地了解允许细菌执行趋化性和趋热性的蛋白质网络，即分别感知和游向食物或偏好的温度。我们建议通过紧密耦合的实验方法和计算建模来发展这样的理解。由于活细胞内的所有信号通路必须在波动的热环境中发挥作用，我们的努力可能揭示细胞确保忠实信号的普遍机制。