System analysis of thermosensation in E. coli

点击翻译按钮获取中文摘要

From a broad perspective, exposure to environmental temperature changes is a universal condition of living organisms. How biochemical and neuronal networks process temperature information or remain robust to temperature variation is not well understood. The aim of this research is to develop a deeper understanding of the network of proteins that allows bacteria to perform chemotaxis and thermotaxis, that is to sense and swim towards food or a preferred temperature, respectively. We propose to develop such an understanding through closely coupled experimental approaches and computational modeling. As all signaling pathways within living cells must function in the context of fluctuating thermal environments, our efforts may reveal universal mechanisms by which cells ensure faithful signaling.