Breed-specific gene expression profiles and DNA methylation patterns in calves infected with Mycobacterium avium subsp. paratuberculosis (MAP)

约翰氏病(JD)是由禽分枝杆菌亚种引起的一种广泛存在的、具有重要经济意义的反刍动物小肠慢性炎症性疾病。副结核(MAP)。据估计，JD在加拿大的患病率在乳牛群中在10%到40%之间，仅乳制品行业就有近1500万美元的收入。奶牛品种对MAP感染的易感性似乎存在差异，球衣比荷斯坦品种更容易感染。在人类中，接触MAP和克罗恩病之间的潜在联系表明，这种病原体似乎也是一个重要的食品安全问题。因此，重要的是，乳品业应制定策略，以减少奶牛MAP感染的发病率，而遗传选择可能是其中一种方法。为了做到这一点，我们正在

Johne's disease (JD) is a widespread and economically important chronic inflammatory disease ofthe small intestine of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP). The prevalence of JD in Canada is estimated to be between 10 and 40% in dairy herds, which accounts for nearly 15 million dollars to the dairy industry, alone. Differences in the susceptibility to MAP infection appear to exist amongst dairy breeds, with Jerseys being more susceptible than the Holstein breed. In humans, a potential link between MAP exposure and Crohn's disease suggests that this pathogen also appears an impOltant food safety concern. Therefore, it is important that the dairy industry develops strategies for reducing the incidence of MAP infections in dairy cattle, and genetic selection might be one such approach. In order to do this, we are