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A systems-level study of the mechanisms leading to RAF dimerization and activation

A systems-level study of the mechanisms leading to RAF dimerization and activation
RAF 二聚化和激活机制的系统级研究
批准号：
247500
负责人：
Lavoie Hugo
金额：
$10.2万
依托单位：
Institute for Research in Immunology and Cancer (Montreal, QC)
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2011
资助国家：
加拿大
项目状态：
已结题
起止时间：
2011-11-01 至 2013-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=247500&lang=en
关键词：
Bioluminescence Cancer Therapies Cellular Biology Fluorescence High-Throughput Screening Molecular Biology Pharmacology Protein-Protein Interactions

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Hyperactivation of RAS/ERK signaling is among the key events leading to tumor initiation and progression. Signaling within this pathway requires the proper assembly of three core kinases (RAF, MEK and ERK) that convey incoming signals by the means of a ph
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A systems-level study of the mechanisms leading to RAF dimerization and activation
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