Toward understanding the molecular mechanisms that regulate intermediate filament keratin functions in hepatocytes

了解调节肝细胞中中间丝角蛋白功能的分子机制

• 批准号: 195539-2011
• 负责人: Cadrin, Monique
• 金额: $ 2.19万
• 依托单位: Université du Québec à Trois-Rivières
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=505864
• 关键词: Toward; understanding; molecular; mechanisms; regulate

Intermediate filaments (IFs) are with microtubules and actin microfilaments the major cytoskeletal components of most mammalian cells. Modifications in K8/18 IFs organization and formation of keratin containing aggregates called Mallory-Denk bodies are common to many human chronic liver diseases such as alcoholic hepatitis, Wilson's disease and liver steatosis in obesity. Recent studies have shown evidences that K8/18 play an important role in the protection of hepatocytes against chronic stress-induced liver injuries.

中间丝（IFs）与微管和肌动蛋白微丝是大多数哺乳动物细胞的主要细胞骨架组成部分。K8/18 IF组织的修饰和称为Mallory-Denk小体的含角蛋白聚集体的形成在许多人类慢性肝病中是常见的，例如酒精性肝炎、威尔逊病和肥胖症中的肝脂肪变性。最近的研究表明，K8/18在肝细胞抗慢性应激性肝损伤中发挥重要作用。