Semaphorin 4C; a novel homing molecule in memory B cell and plasma cell development

信号蛋白 4C；

• 批准号: 402165-2011
• 负责人: Mazer, Bruce
• 金额: $ 2.19万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=505898
• 关键词: Semaphorin; 4C; novel; homing; molecule

B-cell Memory is crucial for rapid, effective and highly targeted immune responses. Long lasting immunity, be it following natural infection or through vaccination, is dependent on the optimal development and location of memory B-lymphocytes. Three subsets of mature B-cells contribute to B-cell memory responses; CD27+ Memory B-cells, plasmablasts, and plasma cells. Through transcriptional profiling, we have identified an important novel surface molecule, Semaphorin 4C, that is specifically expressed in the development of B-memory lineage cells. Our preliminary evidence demonstrates that Sema 4C may be important in B-cell development and in the interaction of circulating B-mem subsets within the matrix of peripheral tissues. Our research program aims to understand the developmental influences on B-cells in airway mucosa. In this proposal, using our well defined murine models, we will build the foundation to elaborate the functional role of Sema 4C in the development of B-cell memory responses.

b细胞记忆对于快速、有效和高度靶向的免疫反应至关重要。无论是自然感染还是通过疫苗接种，持久的免疫都取决于记忆b淋巴细胞的最佳发育和位置。成熟b细胞的三个亚群参与b细胞记忆反应；CD27+记忆b细胞、浆母细胞和浆细胞。通过转录谱分析，我们已经确定了一个重要的新的表面分子，Semaphorin 4C，它在b记忆谱系细胞的发育中特异性表达。我们的初步证据表明，Sema 4C可能在b细胞发育和外周组织基质内循环B-mem亚群的相互作用中起重要作用。我们的研究项目旨在了解气道黏膜对b细胞发育的影响。在本提案中，我们将使用我们定义良好的小鼠模型，为阐述Sema 4C在b细胞记忆反应发展中的功能作用奠定基础。