A genomics and systems level view on species divergence

物种如何在分子和表型水平上分化是进化生物学中最基本的问题之一。在这里，我将利用比较基因组学和系统生物学的最新发展来解决这个问题。使用芽殖酵母酿酒酵母及其密切相关的物种，我将利用遗传学和蛋白质组学的方法来解剖，在分子水平上，在关键表型，区分这些物种的分歧的遗传基础，并比较其蛋白质-蛋白质相互作用网络的架构。我的发现将阐明进化过程，并有助于微生物生物工程领域的关键进展。在该项目中接受培训的人员将拥有保持加拿大在生命科学领域的领先地位所需的尖端技能和创造力，无论是在学术界还是在制药和生物技术行业。

How species become differentiated at the molecular and phenotypic levels is one of the most fundamental questions in evolutionary biology. Here I will take advantage of recent developments in comparative genomics and systems biology to address this question. Using the budding yeast Saccharomyces cerevisiae and its closely related species, I will capitalize on genetics and proteomics approaches to dissect, at the molecular level, the genetic bases of the divergence in key phenotypes that differentiate these species, and compare the architecture of their protein-protein interaction networks. My findings will illuminate the process of evolution and contribute to key advancements in the field of biological engineering of microbial organisms. The personnel trained in this project will have the cutting-edge skills and creativity necessary to maintain Canada's leading position in the life sciences, both in academia and in the pharmaceutical and biotech industries.