Supercritical fluid chromatography in the synthesis of chiral pharmaceuticals, fine chemicals and organic materials

超临界流体色谱在手性药物、精细化学品和有机材料合成中的应用

• 批准号: 440053-2013
• 负责人: Crudden, Cathleen
• 金额: $ 8.95万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=507079
• 关键词: Supercritical; fluid; chromatography; synthesis; chiral

Chirality is a property that many molecules possess, and it is often compared to handedness since chiral molecules are identical except for being right- or left-handed. Chirality is widely prevalent in nature: from the spiral of snail shells to the helical twist in DNA. Nineteen of the twenty essential amino acids are chiral, and in mammalian species, these exist only in their left-handed forms. Since amino acids are the building blocks of peptides, proteins, and enzymes, the biochemical machinery of the body relies on chiral interations.

手性是许多分子都具有的性质，并且它经常与手性进行比较，因为手性分子除了是右手或左手之外是相同的。手性在自然界中广泛存在：从蜗牛壳的螺旋到DNA的螺旋扭曲。 20种必需氨基酸中有19种是手性的，在哺乳动物中，这些氨基酸仅以左手形式存在。 由于氨基酸是肽、蛋白质和酶的基本组成部分，因此人体的生化机制依赖于手性相互作用。