Integrated Biosensors and BioMEMS for Bio-Detection Applications
用于生物检测应用的集成生物传感器和 BioMEMS
基本信息
- 批准号:371896-2012
- 负责人:
- 金额:$ 2.28万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2012
- 资助国家:加拿大
- 起止时间:2012-01-01 至 2013-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The objective of our research program is to generate novel technologies towards integrated sensor systems which will lead to the development of general-purpose, field-usable sensors with ultra-high sensitivity and rapidity. Our biosensing platforms include sensitive high-throughput optical micro-resonator screening array and optical waveguide sensors. These novel biosensing platforms will employ a wide variety of existing and emerging recognition elements including bacteriophages, phage-display, aptamers and molecularly imprinted polymers. We also focus on integrating the biosensors within lab-on-a-chip systems, which allow automatic sample processing (a tedious step prior to the actual analysis) with high level of biocontainment and minimal handling. Fully integrated biosensing platforms offer ultra-sensitive and reliable multi-analyte detection; their miniature size (a single portable device with disposable sample processing chip) allows easy field deployment and ubiquitous applicability. Our biosensors and lab-on-a-chip systems are suitable for use in environmental monitoring, diagnostic and therapeutic applications at and outside point-of-care. The proposed five-year research program is divided into three themes: (A) Development of integrated ultrasonic lab-on-a-chip for rapid biological sample manipulation and detection, (B) Development of optical highthroughput micro-resonator screening platform (lab-on-a-bead), and (C) Development of phage-based theranostic (therapeutics and diagnostics) platforms. Our research provides multidisciplinary training for highly qualified personnel and will generate significant technological know-how, creating a positive impact on Canadian R&D and economy.
我们研究计划的目标是产生集成传感器系统的新技术,这将导致开发出具有超高灵敏度和快速的通用、现场可用传感器。我们的生物传感平台包括灵敏的高通量光学微谐振器筛选阵列和光波导传感器。这些新颖的生物传感平台将使用各种现有的和新兴的识别元件,包括噬菌体、噬菌体展示、适配子和分子印迹聚合物。我们还专注于将生物传感器集成到芯片实验室系统中,该系统允许自动处理样品(实际分析之前的繁琐步骤),具有高水平的生物遏制和最低限度的处理。完全集成的生物传感平台提供超灵敏和可靠的多分析物检测;其微型尺寸(带有一次性样品处理芯片的单个便携式设备)允许轻松现场部署和无处不在的适用性。我们的生物传感器和单芯片实验室系统适用于医疗场所内外的环境监测、诊断和治疗应用。拟议的五年研究计划分为三个主题:(A)开发用于快速生物样本处理和检测的集成超声芯片实验室,(B)开发光学高通量微谐振器筛选平台(Lab-on-a-bead),以及(C)基于噬菌体的治疗和诊断平台的开发。我们的研究为高素质人员提供多学科培训,并将产生重要的技术诀窍,对加拿大的研发和经济产生积极影响。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Zourob, Mohammed其他文献
Development of magnetic nanoparticle based calorimetric assay for the detection of bovine mastitis in cow milk
- DOI:
10.1016/j.ab.2017.02.009 - 发表时间:
2017-04-15 - 期刊:
- 影响因子:2.9
- 作者:
Chinnappan, Raja;Al Attas, Sana;Zourob, Mohammed - 通讯作者:
Zourob, Mohammed
Aptamer-Based Label-Free Electrochemical Biosensor Array for the Detection of Total and Glycated Hemoglobin in Human Whole Blood
- DOI:
10.1038/s41598-017-01226-0 - 发表时间:
2017-04-21 - 期刊:
- 影响因子:4.6
- 作者:
Eissa, Shimaa;Zourob, Mohammed - 通讯作者:
Zourob, Mohammed
An aptamer based fluorometric microcystin-LR assay using DNA strand-based competitive displacement
- DOI:
10.1007/s00604-019-3504-8 - 发表时间:
2019-07-01 - 期刊:
- 影响因子:5.7
- 作者:
Chinnappan, Raja;AlZabn, Razan;Zourob, Mohammed - 通讯作者:
Zourob, Mohammed
Probing high-affinity aptamer binding region and development of aptasensor platform for the detection of cylindrospermopsin
- DOI:
10.1007/s00216-020-02723-4 - 发表时间:
2020-06-04 - 期刊:
- 影响因子:4.3
- 作者:
Chinnappan, Raja;AlZabn, Razan;Zourob, Mohammed - 通讯作者:
Zourob, Mohammed
Development of a Low-Cost Cotton-Tipped Electrochemical Immunosensor for the Detection of SARS-CoV-2
- DOI:
10.1021/acs.analchem.0c04719 - 发表时间:
2021-01-26 - 期刊:
- 影响因子:7.4
- 作者:
Eissa, Shimaa;Zourob, Mohammed - 通讯作者:
Zourob, Mohammed
Zourob, Mohammed的其他文献
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{{ truncateString('Zourob, Mohammed', 18)}}的其他基金
New Class of STC-Multi-h CPM Signals with Low Complexity Decoder for MIMO Wireless Communication Systems: Design, Simulation and Performance Evaluation
用于 MIMO 无线通信系统的具有低复杂度解码器的新型 STC-Multi-h CPM 信号:设计、仿真和性能评估
- 批准号:
444528-2013 - 财政年份:2015
- 资助金额:
$ 2.28万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Doctoral
New Class of STC-Multi-h CPM Signals with Low Complexity Decoder for MIMO Wireless Communication Systems: Design, Simulation and Performance Evaluation
用于 MIMO 无线通信系统的具有低复杂度解码器的新型 STC-Multi-h CPM 信号:设计、仿真和性能评估
- 批准号:
444528-2013 - 财政年份:2014
- 资助金额:
$ 2.28万 - 项目类别:
Postgraduate Scholarships - Doctoral
New Class of STC-Multi-h CPM Signals with Low Complexity Decoder for MIMO Wireless Communication Systems: Design, Simulation and Performance Evaluation
用于 MIMO 无线通信系统的具有低复杂度解码器的新型 STC-Multi-h CPM 信号:设计、仿真和性能评估
- 批准号:
444528-2013 - 财政年份:2013
- 资助金额:
$ 2.28万 - 项目类别:
Postgraduate Scholarships - Doctoral
Development of integrated array biosensing platform for microcystins detection
用于微囊藻毒素检测的集成阵列生物传感平台的开发
- 批准号:
396744-2010 - 财政年份:2012
- 资助金额:
$ 2.28万 - 项目类别:
Strategic Projects - Group
Integrated Lab-on-a-Chip with wireless communication capability for on-site mosquito-borne pathogen detection
具有无线通信功能的集成芯片实验室,用于现场蚊媒病原体检测
- 批准号:
430270-2012 - 财政年份:2012
- 资助金额:
$ 2.28万 - 项目类别:
Strategic Projects - Group
Development of rapid nanostructured biosensor
快速纳米结构生物传感器的开发
- 批准号:
429793-2012 - 财政年份:2012
- 资助金额:
$ 2.28万 - 项目类别:
Engage Grants Program
Development of low-cost, rapid and highly sensitive DNA-based biosensor for routine monitoring of emerging organic compounds in water
开发低成本、快速且高灵敏度的基于 DNA 的生物传感器,用于水中新兴有机化合物的常规监测
- 批准号:
419944-2012 - 财政年份:2012
- 资助金额:
$ 2.28万 - 项目类别:
Strategic Projects - Group
Development of bar-coded, highly sensitive, label-free highthroughput screening platform for endocrine disrubting compounds
开发条形码、高灵敏度、无标记高通量内分泌干扰化合物筛选平台
- 批准号:
430261-2012 - 财政年份:2012
- 资助金额:
$ 2.28万 - 项目类别:
Strategic Projects - Group
Development biosensor for the detection of progesterone hormone as emerging contaminant in water
开发用于检测水中新兴污染物黄体酮激素的生物传感器
- 批准号:
412021-2010 - 财政年份:2011
- 资助金额:
$ 2.28万 - 项目类别:
Engage Grants Program
Development of integrated array biosensing platform for microcystins detection
用于微囊藻毒素检测的集成阵列生物传感平台的开发
- 批准号:
396744-2010 - 财政年份:2011
- 资助金额:
$ 2.28万 - 项目类别:
Strategic Projects - Group
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