Integrated Biosensors and BioMEMS for Bio-Detection Applications

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The objective of our research program is to generate novel technologies towards integrated sensor systems which will lead to the development of general-purpose, field-usable sensors with ultra-high sensitivity and rapidity. Our biosensing platforms include sensitive high-throughput optical micro-resonator screening array and optical waveguide sensors. These novel biosensing platforms will employ a wide variety of existing and emerging recognition elements including bacteriophages, phage-display, aptamers and molecularly imprinted polymers. We also focus on integrating the biosensors within lab-on-a-chip systems, which allow automatic sample processing (a tedious step prior to the actual analysis) with high level of biocontainment and minimal handling. Fully integrated biosensing platforms offer ultra-sensitive and reliable multi-analyte detection; their miniature size (a single portable device with disposable sample processing chip) allows easy field deployment and ubiquitous applicability. Our biosensors and lab-on-a-chip systems are suitable for use in environmental monitoring, diagnostic and therapeutic applications at and outside point-of-care. The proposed five-year research program is divided into three themes: (A) Development of integrated ultrasonic lab-on-a-chip for rapid biological sample manipulation and detection, (B) Development of optical highthroughput micro-resonator screening platform (lab-on-a-bead), and (C) Development of phage-based theranostic (therapeutics and diagnostics) platforms. Our research provides multidisciplinary training for highly qualified personnel and will generate significant technological know-how, creating a positive impact on Canadian R&D and economy.