Development of low-cost, rapid and highly sensitive DNA-based biosensor for routine monitoring of emerging organic compounds in water

开发低成本、快速且高灵敏度的基于 DNA 的生物传感器，用于水中新兴有机化合物的常规监测

• 批准号: 419944-2012
• 负责人: Zourob, Mohammed
• 金额: $ 13.81万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=515817
• 关键词: Development; low; cost; rapid; highly

We are aiming to develop an innovative highthroughput screening sensing platform for the detection and monitoring of Emerging Organic Contaminants (EOCs) in drinking water systems. EOCs correspond to a group of newly detected contaminating compounds with potential health hazards. Authorities are concerned about the potential public health impact of these new contaminants as they are finding their way into different drinking water systems. Among these contaminants are several families of compound that are particularly relevant to public health: antibiotics, hormones and other endocrine disrupting compounds. Highly sensitive detection methods for these compounds are in high demand as they are present only in trace amounts. Current detection methods for EOCs in water rely heavily on expensive analytical instruments and lengthy biological methods that are not suitable for routine field monitoring. We propose here a research program aiming to replace the current detection methodologies with an elegant, cost-effective detection system. This system is capable of

我们的目标是开发一种创新的高通量筛选传感平台，用于检测和监测饮用水系统中的新兴有机污染物（EOC）。EOC对应于一组新检测到的具有潜在健康危害的污染化合物。当局担心这些新污染物可能对公共卫生产生影响，因为它们正在进入不同的饮用水系统。在这些污染物中，有几类化合物与公众健康特别相关：抗生素、激素和其他内分泌干扰化合物。这些化合物的高灵敏度检测方法的需求很高，因为它们仅以痕量存在。目前，水中EOCs的检测方法严重依赖于昂贵的分析仪器和冗长的生物方法，不适合常规现场监测。我们在这里提出了一个研究计划，旨在用一种优雅、具有成本效益的检测系统取代当前的检测方法。该系统能够