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Integrated Lab-on-a-Chip with wireless communication capability for on-site mosquito-borne pathogen detection

具有无线通信功能的集成芯片实验室，用于现场蚊媒病原体检测

基本信息

批准号：
430270-2012
负责人：
Zourob, Mohammed
金额：
$ 15.01万
依托单位：
Institut national de la recherche scientifique
依托单位国家：
加拿大
项目类别：
Strategic Projects - Group
财政年份：
2012
资助国家：
加拿大
起止时间：
2012-01-01 至 2013-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=516463
关键词：
Integrated Lab Chip wireless communication

项目摘要

We are developing an innovative wireless communication-enabled lab-on-a-chip detection platform for on-site detection and monitoring of mosquito-borne diseases. Dangerous viral and bacterial pathogens are transmitted through mosquito vectors, resulting in serious endemic diseases with life-threatening symptoms. Although mosquito eradication programs are in place, the severe acute health effects of these infections necessitate constant detection and monitoring of mosquito-borne pathogens. Current monitoring methodologies share common shortcomings in terms of cost, suitability for field-use, user-friendliness, analysis time, specificity and sensitivity. Here, we propose a detection system that integrates sample treatments, target isolation and detection and wireless data transmission to monitoring offices. We will develop a low-cost, disposable microfluidic biosensor chip that is capable of sample homogenization, isothermal amplification of pathogen RNA/DNA and on-chip detection of amplification products. Integrated with wireless communication capability that seamlessly transmits data to monitoring offices, we can achieve rapid assessment of mosquito-borne pathogen prevalence, allowing timely action to fight against potential outbreaks.

我们正在开发一种创新的无线通信芯片实验室检测平台，用于现场检测和监测蚊媒疾病。危险的病毒和细菌病原体通过蚊子媒介传播，导致具有危及生命症状的严重地方病。虽然消灭蚊子的计划已经到位，但这些感染对健康的严重急性影响需要不断检测和监测蚊子传播的病原体。目前的监测方法在费用、是否适合实地使用、便于使用、分析时间、特异性和敏感性等方面都有共同的缺点。在此，我们提出了一种集样品处理、目标隔离和检测以及无线数据传输到监控室的检测系统。我们将开发一种低成本的一次性微流控生物传感器芯片，该芯片能够进行样品均质、病原体RNA/DNA的等温扩增和扩增产物的片上检测。与无线通信能力相结合，可以无缝地将数据传输到监测办公室，我们可以快速评估蚊媒病原体的流行情况，及时采取行动应对潜在的疫情。