Mechanism of osteoclastic bone resorption: collagenase activity of cathepsin K

破骨细胞骨吸收机制：组织蛋白酶K的胶原酶活性

• 批准号: 268034
• 负责人: Bromme Dieter
• 金额: $ 42.54万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-09-01 至 2017-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=268034&lang=en
• 关键词: Animal Models; Cathepsins; Collagen; Inhibitors; Osteoporosis; Proteases

Osteoporosis affects the lives of millions of Canadians and is a major burden to health care systems worldwide due to an increasing elderly population. Typical treatment regimes such as hormone replacement therapy or bisphosphonates have either various si

骨质疏松症影响着数百万加拿大人的生活，由于老年人口的增加，它是全世界卫生保健系统的主要负担。典型的治疗方案，如激素替代疗法或双膦酸类药物，有不同的疗效