Impact of hypoxia on dichloroacetate (DCA) induced apoptosis

缺氧对二氯乙酸（DCA）诱导细胞凋亡的影响

• 批准号: 105145-2010
• 负责人: Coomber, Brenda
• 金额: $ 2.4万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=521904
• 关键词: Impact; hypoxia; dichloroacetate; DCA; induced

The ability of cells to detect and respond properly to stressful conditions is important for cell survival under a variety of physiological situations, such as temporary changes in blood flow. Cancer cells are able to use these responses to enhance their ability to survive and grow under conditions that might kill normal cells. Recently, it was reported that cancer cells could be selectively killed by treating them with a drug known as DCA. DCA is thought to work by disrupting the way cancer cells use glucose to make energy, something that most cancer cells do differently from normal cells. We have preliminary evidence that, although DCA can kill cancer cells under 'normal' conditions, it actually helps them survive better in stressful environments. We plan to study this effect in detail to determine the cellular pathways used by cancer cells to avoid dieing under these conditions. We hope the information we obtain will help us understand how all cells (normal and cancer) adapt to stressful conditions in healthy and diseased tissue.

细胞检测压力条件并对其做出适当反应的能力对于细胞在各种生理情况下（例如血流的暂时变化）的生存非常重要。 癌细胞能够利用这些反应来增强其在可能杀死正常细胞的条件下生存和生长的能力。 最近，有报道称，用 DCA 药物治疗可以选择性杀死癌细胞。 DCA被认为是通过破坏癌细胞利用葡萄糖产生能量的方式起作用的，而大多数癌细胞的这种方式与正常细胞不同。 我们有初步证据表明，虽然 DCA 可以在“正常”条件下杀死癌细胞，但它实际上可以帮助它们在压力环境中更好地生存。 我们计划详细研究这种效应，以确定癌细胞使用的细胞途径来避免在这些条件下死亡。我们希望我们获得的信息将帮助我们了解所有细胞（正常细胞和癌症细胞）如何适应健康和患病组织的压力条件。