Heart Development and Disease: From Genes to Cures

心脏发育和疾病:从基因到治疗

基本信息

  • 批准号:
    10608624
  • 负责人:
  • 金额:
    $ 1.62万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-02-01 至 2024-01-31
  • 项目状态:
    已结题

项目摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled Heart Development and Disease: From Genes to Cures, organized by Drs. Sean Wu, Wolfram Zimmermann and Christine Seidman. The conference will be held in Santa Fe, New Mexico from February 12-15, 2023. Significant advances in recent years in mechanistic understanding of cardiac development, function, and degeneration have stimulated interest in identifying novel therapeutic agents that may help treat children and adult patients with cardiovascular diseases. However, therapies developed in cell and animal models rarely translate well to human patients. The goals of this conference are to advance our understanding of heart formation and homeostatic function and how derangement in these processes lead to diseases and organ dysfunction. Since human cardiovascular tissue is difficult to obtain for experimental perturbation this conference will address the use of a spectrum of cells and engineered tissue models as well as small and large animal models of disease. This conference will also feature the state-of-the art tools and technologies that have revolutionized the developments in various domains of cardiovascular research including heart developmental biology, genetics of cardiomyopathy and congenital heart disease, cardiac tissue engineering, and cell and regenerative therapy. This event will bring together scientists with diverse research backgrounds who employ different tools and technologies to address mechanisms of cardiomyocyte and vascular dysfunction and will uncover new approaches to cardiovascular biology. The program is designed to showcase innovative, molecularly targeted strategies to treat both rare and common cardiovascular diseases.
摘要 要求支持一个基石研讨会会议题为心脏发育和疾病:从 基因治疗,由肖恩吴博士,沃尔夫勒姆齐默尔曼和克莉丝汀塞德曼组织。会议 将于2023年2月12日至15日在新墨西哥州圣达菲举行。 近年来,在心脏发育、功能和 变性的研究激发了人们对鉴定新的治疗剂的兴趣, 成年心血管疾病患者。然而,在细胞和动物模型中开发的疗法很少 很好地转化为人类患者。本次会议的目标是促进我们对心脏的理解 以及这些过程的紊乱如何导致疾病和器官损伤。 功能障碍由于人体心血管组织难以获得用于实验扰动, 会议将讨论一系列细胞和工程组织模型的使用,以及小型和大型 疾病的动物模型。本次会议还将展示最先进的工具和技术, 已经彻底改变了心血管研究各个领域的发展, 发育生物学,心肌病和先天性心脏病的遗传学,心脏组织工程, 以及细胞和再生疗法。这项活动将汇集具有不同研究背景的科学家 他们使用不同的工具和技术来解决心肌细胞和血管 并将揭示心血管生物学的新方法。该计划旨在 展示创新的分子靶向策略,以治疗罕见和常见的心血管疾病。

项目成果

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TERRY L. SHEPPARD其他文献

TERRY L. SHEPPARD的其他文献

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{{ truncateString('TERRY L. SHEPPARD', 18)}}的其他基金

Pulmonary Hypertension: State of the Art and Therapeutic Opportunities
肺动脉高压:最新技术和治疗机会
  • 批准号:
    10682118
  • 财政年份:
    2023
  • 资助金额:
    $ 1.62万
  • 项目类别:
Infections in Pregnancy: PathogenicMechanisms, Experimental Advances and Clinical Strategies
妊娠期感染:致病机制、实验进展和临床策略
  • 批准号:
    10540260
  • 财政年份:
    2023
  • 资助金额:
    $ 1.62万
  • 项目类别:
Mechanisms of Microbiota-Immune Interactions-Towards the Next Decade
微生物群-免疫相互作用的机制-迈向下一个十年
  • 批准号:
    10753451
  • 财政年份:
    2023
  • 资助金额:
    $ 1.62万
  • 项目类别:
Vaccinology During and After COVID-19
COVID-19 期间和之后的疫苗学
  • 批准号:
    10753782
  • 财政年份:
    2023
  • 资助金额:
    $ 1.62万
  • 项目类别:
Transposable Elements at the Crossroads of Evolution, Health and Disease
处于进化、健康和疾病十字路口的转座元件
  • 批准号:
    10750852
  • 财政年份:
    2023
  • 资助金额:
    $ 1.62万
  • 项目类别:
Long COVID and Post Acute Sequalae of SARS CoV 2 (PASC): Pathogenesis and Treatment
长期新冠肺炎和 SARS CoV 2 (PASC) 急性后遗症:发病机制和治疗
  • 批准号:
    10749522
  • 财政年份:
    2023
  • 资助金额:
    $ 1.62万
  • 项目类别:
B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers
传染病、自身免疫和 B 细胞癌症背景下的 B 细胞生物学
  • 批准号:
    10683443
  • 财政年份:
    2023
  • 资助金额:
    $ 1.62万
  • 项目类别:
HIV Vaccines, Immunoprophylaxis and Drugs
HIV 疫苗、免疫预防和药物
  • 批准号:
    10699245
  • 财政年份:
    2023
  • 资助金额:
    $ 1.62万
  • 项目类别:
Metastasis
转移
  • 批准号:
    10681132
  • 财政年份:
    2023
  • 资助金额:
    $ 1.62万
  • 项目类别:
Inflammation in the Lung: Friend or Foe in Viral Infections?
肺部炎症:病毒感染的朋友还是敌人?
  • 批准号:
    10681956
  • 财政年份:
    2023
  • 资助金额:
    $ 1.62万
  • 项目类别:

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