Heart Development and Disease: From Genes to Cures

心脏发育和疾病：从基因到治疗

• 批准号: 10608624
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.62万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608624
• 关键词: Acceleration; Address; Adult; Animal Disease Models; Animal Model; Biology; Biophysics; Cardiac; Cardiac Myocytes; Cardiovascular Diseases; Cardiovascular system; Cell Therapy; Cell model; Cells; Child; Clinical Trials; Collaborations; Development; Developmental Biology; Disadvantaged; Disease; Disease Progression; Disease model; Educational workshop; Event; Fertilization; Functional disorder; Genes; Genetic; Goals; Health Expenditures; Heart; Heart Diseases; Human; Investigation; Knowledge; Lead; Learning; Mediator; Medical; Methodology; Molecular Target; Morbidity - disease rate; New Mexico; Onset of illness; Operative Surgical Procedures; Organ; Outcome; Pathogenesis; Patients; Population; Process; Research; Research Personnel; Scientist; Signal Pathway; Techniques; Technology; Therapeutic Agents; Tissue Engineering; Tissue Model; Tissues; Translating; Translations; Tungsten; Vascular Diseases; Work; aging population; cardiac repair; cardiac tissue engineering; cardiogenesis; clinical application; clinical practice; congenital heart disorder; design; improved; in vitro Model; in vivo Model; inherited cardiomyopathy; innovation; insight; interest; meetings; mortality; novel; novel strategies; novel therapeutics; posters; programs; regenerative biology; regenerative therapy; stem cell model; stem cells; symposium; therapeutic development; therapy development; tool; translational therapeutics; treatment strategy

ABSTRACT Support is requested for a Keystone Symposia conference entitled Heart Development and Disease: From Genes to Cures, organized by Drs. Sean Wu, Wolfram Zimmermann and Christine Seidman. The conference will be held in Santa Fe, New Mexico from February 12-15, 2023. Significant advances in recent years in mechanistic understanding of cardiac development, function, and degeneration have stimulated interest in identifying novel therapeutic agents that may help treat children and adult patients with cardiovascular diseases. However, therapies developed in cell and animal models rarely translate well to human patients. The goals of this conference are to advance our understanding of heart formation and homeostatic function and how derangement in these processes lead to diseases and organ dysfunction. Since human cardiovascular tissue is difficult to obtain for experimental perturbation this conference will address the use of a spectrum of cells and engineered tissue models as well as small and large animal models of disease. This conference will also feature the state-of-the art tools and technologies that have revolutionized the developments in various domains of cardiovascular research including heart developmental biology, genetics of cardiomyopathy and congenital heart disease, cardiac tissue engineering, and cell and regenerative therapy. This event will bring together scientists with diverse research backgrounds who employ different tools and technologies to address mechanisms of cardiomyocyte and vascular dysfunction and will uncover new approaches to cardiovascular biology. The program is designed to showcase innovative, molecularly targeted strategies to treat both rare and common cardiovascular diseases.

抽象的 请求支持题为“心脏发育与疾病：来自”的 Keystone 研讨会 从基因到治愈，由 Drs 组织。肖恩·吴、沃尔夫拉姆·齐默尔曼和克里斯汀·塞德曼。会议 将于2023年2月12日至15日在新墨西哥州圣达菲举行。 近年来，对心脏发育、功能和心脏功能的机制理解取得了重大进展。 变性激发了人们对寻找可能有助于治疗儿童和儿童的新型治疗剂的兴趣。 患有心血管疾病的成年患者。然而，在细胞和动物模型中开发的疗法很少 可以很好地转化为人类患者。这次会议的目标是增进我们对心脏的理解 形成和稳态功能以及这些过程的紊乱如何导致疾病和器官 功能障碍。由于人类心血管组织很难获得用于实验扰动，因此 会议将讨论一系列细胞和工程组织模型以及小型和大型的使用 疾病动物模型。本次会议还将展示最先进的工具和技术 彻底改变了心血管研究各个领域的发展，包括心脏 发育生物学、心肌病和先天性心脏病遗传学、心脏组织工程、 以及细胞和再生疗法。该活动将汇集具有不同研究背景的科学家 他们采用不同的工具和技术来解决心肌细胞和血管的机制 功能障碍并将揭示心血管生物学的新方法。该计划旨在 展示治疗罕见和常见心血管疾病的创新分子靶向策略。