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Heart Development and Disease: From Genes to Cures

心脏发育和疾病：从基因到治疗

基本信息

批准号：
10608624
负责人：
TERRY L. SHEPPARD
金额：
$ 1.62万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-01 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10608624
关键词：
Acceleration Address Adult Animal Disease Models Animal Model Biology Biophysics Cardiac Cardiac Myocytes Cardiovascular Diseases Cardiovascular system Cell Therapy Cell model Cells Child Clinical Trials Collaborations Development Developmental Biology Disadvantaged Disease Disease Progression Disease model Educational workshop Event Fertilization Functional disorder Genes Genetic Goals Health Expenditures Heart Heart Diseases Human Investigation Knowledge Lead Learning Mediator Medical Methodology Molecular Target Morbidity - disease rate New Mexico Onset of illness Operative Surgical Procedures Organ Outcome Pathogenesis Patients Population Process Research Research Personnel Scientist Signal Pathway Techniques Technology Therapeutic Agents Tissue Engineering Tissue Model Tissues Translating Translations Tungsten Vascular Diseases Work aging population cardiac repair cardiac tissue engineering cardiogenesis clinical application clinical practice congenital heart disorder design improved in vitro Model in vivo Model inherited cardiomyopathy innovation insight interest meetings mortality novel novel strategies novel therapeutics posters programs regenerative biology regenerative therapy stem cell model stem cells symposium therapeutic development therapy development tool translational therapeutics treatment strategy

项目摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled Heart Development and Disease: From Genes to Cures, organized by Drs. Sean Wu, Wolfram Zimmermann and Christine Seidman. The conference will be held in Santa Fe, New Mexico from February 12-15, 2023. Significant advances in recent years in mechanistic understanding of cardiac development, function, and degeneration have stimulated interest in identifying novel therapeutic agents that may help treat children and adult patients with cardiovascular diseases. However, therapies developed in cell and animal models rarely translate well to human patients. The goals of this conference are to advance our understanding of heart formation and homeostatic function and how derangement in these processes lead to diseases and organ dysfunction. Since human cardiovascular tissue is difficult to obtain for experimental perturbation this conference will address the use of a spectrum of cells and engineered tissue models as well as small and large animal models of disease. This conference will also feature the state-of-the art tools and technologies that have revolutionized the developments in various domains of cardiovascular research including heart developmental biology, genetics of cardiomyopathy and congenital heart disease, cardiac tissue engineering, and cell and regenerative therapy. This event will bring together scientists with diverse research backgrounds who employ different tools and technologies to address mechanisms of cardiomyocyte and vascular dysfunction and will uncover new approaches to cardiovascular biology. The program is designed to showcase innovative, molecularly targeted strategies to treat both rare and common cardiovascular diseases.

摘要要求支持一个基石研讨会会议题为心脏发育和疾病：从基因治疗，由肖恩吴博士，沃尔夫勒姆齐默尔曼和克莉丝汀塞德曼组织。会议将于2023年2月12日至15日在新墨西哥州圣达菲举行。近年来，在心脏发育、功能和变性的研究激发了人们对鉴定新的治疗剂的兴趣，成年心血管疾病患者。然而，在细胞和动物模型中开发的疗法很少很好地转化为人类患者。本次会议的目标是促进我们对心脏的理解以及这些过程的紊乱如何导致疾病和器官损伤。功能障碍由于人体心血管组织难以获得用于实验扰动，会议将讨论一系列细胞和工程组织模型的使用，以及小型和大型疾病的动物模型。本次会议还将展示最先进的工具和技术，已经彻底改变了心血管研究各个领域的发展，发育生物学，心肌病和先天性心脏病的遗传学，心脏组织工程，以及细胞和再生疗法。这项活动将汇集具有不同研究背景的科学家他们使用不同的工具和技术来解决心肌细胞和血管并将揭示心血管生物学的新方法。该计划旨在展示创新的分子靶向策略，以治疗罕见和常见的心血管疾病。