Synthesis and evaluation of new scaffolds to control protein-protein and protein-dna interactions
Synthesis and evaluation of new scaffolds to control protein-protein and protein-dna interactions
批准号:
355466-2011
负责人:
Wulff, Jeremy
金额:
$2.55万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-01-01 至 2014-12-31
中文摘要
我的研究小组主要关注蛋白质-蛋白质或蛋白质- dna相互作用调节支架的合成和生物学评价。我们所有的项目都有明确的生物学目标,但最让我们感兴趣的是潜在的化学合成。为了最大限度地训练学生,我们有意选择困难的合成目标(无论是天然产物还是设计的分子),这迫使我们发明新的合成方法。通过应对这些艰巨的合成挑战,我的学生成为了合成有机化学方面的专家,为他们在工业界(特别是制药和生物技术部门)和学术界的职业生涯做好了充分的准备。
英文摘要
The principal focus for my research group is the synthesis and biological evaluation of scaffolds for the modulation of protein-protein or protein-DNA interactions. All of our projects have defined biological goals, but it is the underlying chemical synthesis that most interests us. In an effort to maximize student training, we intentionally choose difficult synthetic targets (whether natural products or designed molecules) that force us to invent new synthetic methodology. Through the process of answering these arduous synthetic challenges, my students become experts in synthetic organic chemistry, leaving them well-prepared for careers in both industry (particularly the pharmaceutical and biotechnology sectors) and academia.
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会议论文
Defining New Biological and Chemical Targets With Diazirines
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批准号:RGPIN-2021-02560
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.5万
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财政年份:2022
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负责人:Wulff, Jeremy
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依托单位:
Bioactive Small Molecule Synthesis
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批准号:CRC-2016-00290
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项目类别:Canada Research Chairs
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资助金额:$5.46万
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财政年份:2021
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负责人:Wulff, Jeremy
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依托单位:
Defining New Biological and Chemical Targets With Diazirines
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批准号:RGPIN-2021-02560
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.5万
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财政年份:2021
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负责人:Wulff, Jeremy
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依托单位:
Bioactive Small Molecule Synthesis
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批准号:CRC-2016-00290
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项目类别:Canada Research Chairs
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资助金额:$7.29万
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财政年份:2020
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负责人:Wulff, Jeremy
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依托单位:
Total Synthesis of Unnatural Products
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批准号:RGPIN-2016-04283
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.35万
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财政年份:2020
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负责人:Wulff, Jeremy
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依托单位:
Total Synthesis of Unnatural Products
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批准号:RGPIN-2016-04283
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.35万
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财政年份:2019
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负责人:Wulff, Jeremy
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依托单位:
Bioactive Small Molecule Synthesis
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批准号:CRC-2016-00290
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项目类别:Canada Research Chairs
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资助金额:$7.29万
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财政年份:2019
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负责人:Wulff, Jeremy
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依托单位:
Analytical methods to enhance manufacturability of latex elastrator rings
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批准号:538474-2019
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项目类别:Engage Plus Grants Program
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资助金额:$0.91万
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财政年份:2019
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负责人:Wulff, Jeremy
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依托单位:
Total Synthesis of Unnatural Products
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批准号:RGPIN-2016-04283
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.35万
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财政年份:2018
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负责人:Wulff, Jeremy
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依托单位:
Tuning lidocaine delivery from latex elastrator rings
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批准号:531133-2018
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项目类别:Engage Grants Program
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资助金额:$1.82万
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财政年份:2018
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负责人:Wulff, Jeremy
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依托单位:
Bioactive Small Molecule Synthesis
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批准号:CRC-2016-00290
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项目类别:Canada Research Chairs
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资助金额:$7.29万
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财政年份:2018
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负责人:Wulff, Jeremy
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依托单位:
Monitoring terpene profiles in beer as a response to hopping conditions
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批准号:522165-2017
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项目类别:Engage Grants Program
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资助金额:$1.82万
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财政年份:2017
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负责人:Wulff, Jeremy
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依托单位:
Total Synthesis of Unnatural Products
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批准号:RGPIN-2016-04283
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.35万
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财政年份:2017
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负责人:Wulff, Jeremy
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依托单位:
Bioactive Small Molecule Synthesis
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批准号:CRC-2016-00290
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项目类别:Canada Research Chairs
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资助金额:$7.29万
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财政年份:2017
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负责人:Wulff, Jeremy
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依托单位:
Bioactive Small Molecule Synthesis
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批准号:1000226685-2011
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项目类别:Canada Research Chairs
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资助金额:$5.46万
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财政年份:2016
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负责人:Wulff, Jeremy
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依托单位:
Bioactive Small Molecule Synthesis
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批准号:CRC-2016-00290
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项目类别:Canada Research Chairs
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资助金额:$1.82万
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财政年份:2016
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负责人:Wulff, Jeremy
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依托单位:
Total Synthesis of Unnatural Products
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批准号:RGPIN-2016-04283
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.35万
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财政年份:2016
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负责人:Wulff, Jeremy
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依托单位:
High-level characterization of the effects of de-icing salts on polymer composite insulator shed hydrophobicity and monomer leakage
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批准号:500759-2016
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项目类别:Engage Grants Program
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资助金额:$1.82万
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财政年份:2016
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负责人:Wulff, Jeremy
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依托单位:
Functionalized Polydicyclopentadiene: Reduction to Commercially Viable Pratice (I2I Phase 1)
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批准号:501981-2016
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项目类别:Idea to Innovation
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资助金额:$9.11万
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财政年份:2016
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负责人:Wulff, Jeremy
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依托单位:
Synthesis and evaluation of new scaffolds to control protein-protein and protein-dna interactions
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批准号:355466-2011
-
项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
-
财政年份:2015
-
负责人:Wulff, Jeremy
-
依托单位:
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