Development of methodology to measure the cell-induced force in 3-D space

开发测量 3D 空间中细胞诱导力的方法

• 批准号: 372236-2010
• 负责人: Kwon, HyockJu
• 金额: $ 2.11万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528520
• 关键词: Development; methodology; measure; cell; induced

Cell migration is essential to living organisms. Tissue formation, wound healing, inflammation and immune response are all driven by cell traction forces (CTF) that act on the extracellular matrix (ECM) to push and pull the cells along. Unfortunately, the generation and regulation of CTF is also vital to the propagation of cancer, osteoporosis and cardiovascular disease.

细胞迁移对于活着的有机体来说是必不可少的。组织形成、伤口愈合、炎症和免疫反应都是由细胞牵引力(CTF)驱动的，细胞牵引力作用于细胞外基质(ECM)，推动和拉动细胞前进。不幸的是，CTF的产生和调节在癌症、骨质疏松症和心血管疾病的传播中也是至关重要的。