Measurement of 3D Cell Dynamics: Forces and Vibrations

3D 细胞动力学测量：力和振动

• 批准号: RGPIN-2015-04118
• 负责人: Kwon, HyockJu
• 金额: $ 1.6万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638494
• 关键词: Measurement; 3D; Cell; Dynamics; Forces

The mechanical behaviour of cells is altered by various diseases such as cancer, arthritis and cardiovascular disease. In particular, dynamic mechanical behaviour provides a key to diagnosing diseases and identifying malignant cells, as it reveals the metabolic state and metastatic ability of a cell. Specifically, the study of the dynamics of cell migration and cell wall vibration form an engineering research program of considerable potential. The proposed research program will develop methods to investigate these dynamic activities and obtain a fundamental understanding of them, with the intent to determine the interplay between them, which will form the basis for integrated diagnostic tools used to identify metastatic diseases.

细胞的机械行为会因癌症、关节炎和心血管疾病等各种疾病而改变。特别是，动态力学行为提供了诊断疾病和识别恶性细胞的关键，因为它揭示了细胞的代谢状态和转移能力。具体而言，细胞迁移和细胞壁振动的动力学研究形成了相当大的潜力的工程研究计划。拟议的研究计划将开发研究这些动态活动的方法，并对其进行基本了解，以确定它们之间的相互作用，这将成为用于识别转移性疾病的综合诊断工具的基础。