Hydrogel materials as radiation dosimeter for 3D dose distribution mapping

要做的工作的性质：放射治疗是一种常规的临床实践，它可以摧毁癌细胞并缩小目标区域的肿瘤。传统上，放射治疗是在二维（即宽度和高度）中进行的。然而，计算机断层扫描（CT）和磁共振成像（MRI）等实体肿瘤成像技术的快速发展，使得三维（3D；宽度、高度和深度）放射治疗得以使用，从而使放射源更精确地靶向目标肿瘤成为可能。尽管在复杂的三维靶体积中定位肿瘤和提供高一致性和精度的治疗放射方面取得了进展，但三维剂量分布的测量尚未得到匹配。本CRD提案的目标是设计天然存在和合成水凝胶材料的辐射剂量测量套件（剂量计）。这项研究的重要性：由于CT和mri成像技术的进步，目前的放射治疗得到了极大的加强。一旦目标被确定，那么精确数量的辐射就会沉积到目标区域。然而，究竟有多少沉积的辐射分布在目标是未知的。这就要求设计出能够精确测量三维吸收剂量分布的剂量计（辐射剂量测量套件）。因此，本研究对临床放射设施具有重要意义。缺乏对剂量分布的测量使患者在治疗中面临更大的系统性和随机错误的风险。预期结果：我们预期拟议的研究将解决临床相关剂量计设计中的挑战。对加拿大的好处：癌症是加拿大的主要死亡原因之一。加拿大癌症协会估计，每年约有17.4万名患者被诊断患有癌症。其中一些患者最终将接受放射治疗。迫切需要精确测量沉积辐射的剂量计。拥有这项技术将使合作的私营公司能够成功地营销产品并创造就业机会。

THE NATURE OF THE WORK TO BE DONE: Radiation therapy, which destroys cancer cells and shrinks tumors in a target area, is a routine clinical practice. Traditionally, radiation treatments have been carried out intwo dimensions (i.e. width and height). Rapid advances in imaging techniques for solid tumor such as computed tomography(CT) and magnetic resonance imaging (MRI), however, allowed the use of three-dimension (3D; width, height, and depth) radiation therapywhere more precise targeting of a target tumorwith radiation sources is possible. Despite the advances made to locate the tumor and to deliver therapeutic radiation in complex 3D target volume with high conformityand precision, measurement of 3D dose distribution has not been matched. The goal of this CRD proposal is to design radiation dose measuring kits (dosimeters) from naturally occurring and synthetic hydrogel materials. WHY AND TO WHOM THE RESEARCH IS IMPORTANT: Current radiation treatment is highlyaugmented bythe advances made in CT and MRIimaging. Once the target is identified then precise amounts of radiation is deposited to the target area. However, exactlyhow much of the deposited radiation is distributed in the target is unknown. This demands the design of dosimeters (radiation dose measuring kits) which can accuratelyand preciselymeasure 3D absorbed dose distributions. Therefore the proposed research is important to clinical radiation facilities. The lack of measuring dose distribution leaves patients exposed to increased risk of systematic and random errors in therapy. THE ANTICIPATED OUTCOME: We anticipate the proposed research to address the challenges in the design of clinically-relevant dosimeters. BENEFITS TO CANADA: Cancer is one of the leading causes of death in Canada. The Canadian cancer Societyestimates that everyyear some 174,000 patients are diagnosed with Cancer. Some of these patients will ultimatelyundergo radiation therapy. The need for dosimeters that accuratelymeasure deposited radiation is urgent. Having this technologywill allow the collaborating private companyto be successful in marketing the product and creating jobs.