Simultaneous optical imaging of oxygenation and blood flow for chronic monitoring of stroke and seizure activity

氧合和血流的同步光学成像，用于长期监测中风和癫痫活动

• 批准号: 413747-2012
• 负责人: Levi, Ofer
• 金额: $ 13.11万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=530819
• 关键词: Simultaneous; optical; imaging; oxygenation; blood

Patients surviving ischemic stroke often express delayed epileptic syndromes. Late poststroke seizures occur after a latency period lasting from several months to years after the insult. These seizures might result from ischemia-induced neuronal death and associated morphological and physiological changes that are only partly elucidated. There is a need for low-cost imaging technique that will observe these changes and assist in treatment evaluation. We have recently shown that wide field optical imaging can be used for fast simultaneous imaging of blood flow and oxygenation in a rodent brain, a surrogate to neural activity. Building on ongoing collaboration for the past two years with researchers and clinicians in Toronto's hospitals and with QImaging, a worldwide leading biomedical imaging camera maker from Surrey, BC, we will translate these results to

存活的缺血性中风患者常表现迟发性癫痫综合征。脑卒中后晚期癫痫发作发生在脑卒中后数月至数年的潜伏期后。这些癫痫发作可能是由缺血引起的神经元死亡和相关的形态学和生理学变化引起的，这些变化仅部分阐明。需要低成本的成像技术来观察这些变化并协助治疗评估。我们最近的研究表明，宽视场光学成像可以用于快速同时成像啮齿动物大脑中的血流和氧合，这是神经活动的替代。在过去两年中，我们与多伦多医院的研究人员和临床医生以及来自不列颠哥伦比亚省萨里市的全球领先的生物医学成像相机制造商QImaging进行了持续的合作，我们将把这些成果转化为