Novel mechanisms of early growth response-1 activation through the epidermal growth factor receptor

通过表皮生长因子受体激活早期生长反应1的新机制

• 批准号: DP120101557
• 负责人: Prof Levon Khachigian
• 金额: $ 20.45万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP120101557
• 关键词: Novel; mechanisms; early; growth; response

This project will expand our knowledge of how cytokines and growth factors switch on signalling pathways from the cell surface to the nucleus. Unique antibodies will characterise regulatory routes, state-of-the-art microscopy will define dynamic patterns of receptor co-assembly, and in vivo studies will show receptor crosstalk in animal models.

这个项目将扩大我们对细胞因子和生长因子如何开启从细胞表面到细胞核的信号通路的认识。独特的抗体将描述调控途径，最先进的显微镜将定义受体共组装的动态模式，体内研究将显示动物模型中的受体串扰。