Novel Small Molecule FosB/AP-1 Inhibitors for the Prevention of Proliferative Vascular Disorders

用于预防增殖性血管疾病的新型小分子 FosB/AP-1 抑制剂

• 批准号: nhmrc : 1030769
• 负责人: Prof Levon Khachigian
• 金额: $ 22.91万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-small-molecule-vascular-disorders/110774
• 关键词: Novel; Small; Molecule; FosB; AP

This project examines the effect of a novel FosB/AP-1 inhibitor (LK001) on neointima formation after injury in animal models of restenosis, atherosclerosis and abdominal aortic aneurysm, and a human ex vivo model of graft stenosis Given the current prevalence of CVD in Australia and the increasing demographic of susceptible individuals in the ageing population, this project has enormous clinical implications.

该项目研究了一种新型FosB/AP-1抑制剂（LK 001）对再狭窄、动脉粥样硬化和腹主动脉瘤动物模型以及移植物狭窄的人类离体模型损伤后新生内膜形成的影响。鉴于澳大利亚目前CVD的患病率以及老龄化人群中易感个体的人口统计学增加，该项目具有巨大的临床意义。