YrdC translational control: physical and functional interactions, identification and influence of amino acid phosphorylation

YrdC 翻译控制：物理和功能相互作用、氨基酸磷酸化的识别和影响

• 批准号: DP0985891
• 负责人: Prof Levon Khachigian
• 金额: $ 23.59万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0985891
• 关键词: YrdC; translational; control; physical; functional

This project will expand our basic understanding of the mechanisms with which a newly identified and highly conserved protein, YrdC203 regulates the process of protein synthesis from mRNA. This work will lead to basic insights into how gene expression is regulated at the level of translation, and generate valuable research tools, such as YrdC203 knockdown tools, peptide mimetics and decoys, phospho-specific and phospho-non specific antibodies. Exploitation of this breakthrough science will open up new avenues for therapeutic intervention in the future, while commercial exploitation of such reagents that recognise or interfere with YrdC203 will generate economic returns to Australia.

该项目将扩大我们对一种新发现的高度保守的蛋白质YrdC203调节mRNA合成蛋白质过程的机制的基本理解。这项工作将导致对基因表达如何在翻译水平上调节的基本见解，并产生有价值的研究工具，如YrdC203敲除工具，肽模拟物和诱饵，磷酸特异性和磷酸非特异性抗体。 这一突破性科学的开发将为未来的治疗干预开辟新的途径，而识别或干扰YrdC203的此类试剂的商业开发将为澳大利亚带来经济回报。