Activation Transcription Factor-4: Novel Regulator of Smooth Muscle Cell Repair and Intimal Thickening through Tenascin C

激活转录因子 4：通过腱蛋白 C 调节平滑肌细胞修复和内膜增厚

• 批准号: nhmrc : 1030767
• 负责人: Prof Levon Khachigian
• 金额: $ 15.22万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/activation-transcription-factor-tenascin-c/110773
• 关键词: Activation; Transcription; Factor; Novel; Regulator

CVD represents the most important cause of morbidity and mortality in the world, accounting for 35% of all deaths in Australia. Smooth muscle cell growth accounts for a range of vascular proliferative disorders. This project focuses on understanding the role of ATF-4 as a new key regulator of SMC proliferation and intimal thickening in injured vessels. Moreover, strategies targeting ATF-4 will facilitate future therapeutic strategies to control intimal thickening in patients with vascular disease.

CVD是世界上发病率和死亡率最重要的原因，占澳大利亚所有死亡人数的35%。平滑肌细胞生长导致一系列血管增生性疾病。该项目的重点是了解ATF-4作为损伤血管中SMC增殖和内膜增厚的新关键调节因子的作用。此外，靶向ATF-4的策略将有助于未来控制血管疾病患者内膜增厚的治疗策略。