Anti-inflammatory effects of a synthetic di-phosphoserine (PP2) egg yolk peptide in modulating inflammatory response

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Inflammation is now thought to be the central to etiology of many diseases. Phosphopeptides are one among the most interesting biomolecules and these functional bioactive peptides have shown the most promising anti-inflammatory potential as therapeutic or health promoting agents. Phosphopeptides usually contain clusters of phosphoserines, which have been shown earlier to exert immunomodulatory, anti-inflammatory and anti-oxidative stress effects. However, the role of phosphoserine residues- the key molecules that exert the function and their mechanism of action remain unknown. The role of a synthetic di-phosphoserine peptides, PP-2, in modulating inflammation will therefore be examined using inflammation induced in vitro models of Caco-2, HT-29 and RAW264.7 human cell lines. Potential signalling mechanisms via quantitative RT-PCR array and cytokine mediators of gene and protein expressions will be elucidated and characterized.