Investigation of ultraviolet light effects on animal cell culture media and ultraviolet light potential in biopharma processes

研究紫外线对动物细胞培养基的影响以及生物制药过程中的紫外线潜力

• 批准号: 460753-2013
• 负责人: Aucoin, Marc
• 金额: $ 0.91万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Engage Plus Grants Program
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=542276
• 关键词: Investigation; ultraviolet; light; effects; animal

One of the major challenges faced by the biopharmaceutical industry is the production of therapeutics with sterility assurance levels of terminally sterilized products throughout the entire manufacturing process. Biotherapeutics are produced by cultivating living cells (bacteria, yeast, insect, and mammalian) in a nutrient solution (also known as a medium), whose composition is based on the growth requirements of the cells. The composition and sterility of the media are critical for any cell culture derived products. This initiative aims to capitalize on the success achieved from studies pursued as part of an Engage Grant. The former has led to the preparation of a manuscript and Trojan filing for a patent related to the work conducted as part of he Engage grant. Prof. Aucoin has led an investigation into the effects of UV on cell culture media and its effects on he

生物制药行业面临的主要挑战之一是在整个制造过程中生产最终灭菌产品的无菌保证水平的治疗药物。生物疗法是通过在营养液(也称为介质)中培养活细胞(细菌、酵母、昆虫和哺乳动物)而产生的，营养液的组成基于细胞的生长要求。培养液的组成和无菌对任何细胞培养衍生产品都是至关重要的。这一倡议的目的是利用作为社会参与补助金一部分进行的研究所取得的成功。前者导致编写了一份手稿，并为一项专利提交了特洛伊木马程序，这项专利是作为他从事的授权的一部分进行的。Aucoin教授领导了一项关于紫外线对细胞培养液的影响及其对HE的影响的研究。